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    Article

    A phylogenetic comparison of mutation spectra

    Spectra of induced mutations resulting in obligate organoauxotrophy are compared at different phylogenetic levels from bacteria to higher plants. It appears that the spectra of mutants concerned with basic cel...

    S. L. Li, G. P. Rédei, C. Shields Gowans in Molecular and General Genetics MGG (1967)

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    Article

    Thiamine mutants of the crucifer, Arabidopsis

    In higher plants the only obligate organoauxotrophic mutants available are concerned with the synthesis of thiamine, vitamin B1. In Arabidopsis 65 mutants, representing four loci controlling four different steps ...

    S. L. Li, G. P. Rédei in Biochemical Genetics (1969)

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    Article

    A study of genetic polymorphisms of milk β-lactoglobulin, αS1-casein, β-casein, and κ-casein in five dairy breeds

    Gene frequencies of the milk β-lactoglobulin, αS1-casein, β-casein, and κ-casein loci have been estimated from 1663 cows of five dairy breeds. Departure from Hardy-Weinberg equilibrium was found only in the κ-cas...

    Francis H. F. Li, Stanley N. Gaunt in Biochemical Genetics (1972)

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    Article

    Nucleotide sequence divergence among DNA fractions of different syngens of Tetrahymena pyriformis

    The magnitude of the differences in base sequence of DNA fractions derived from different syngens of the ciliated protozoan Tetrahymena pyriformis was investigated. Each DNA was fractionated into unique and repea...

    Sally Lyman Allen, Chi Ing Li in Biochemical Genetics (1974)

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    Article

    A virus-specified mechanism for the prevention of multiple infection—T7- and T3-mutual and superinfection exclusion

    Co-and superinfection of cells with T3/T7 result in exclusion (mutual or superinfection exclusion). The exclusion mechanism is also directed against homologous (or identical) virus. Exclusion is established af...

    Monica Hirsch-Kauffmann, Mei-li Pfennig-Yeh in Molecular and General Genetics MGG (1976)

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    Article

    E. coli membranes become permeable to ions following T7-virus-infection

    Infection of E. coli with the viruses T7 or T3 leads to a dramatic efflux of potassium ions. This ion efflux is caused by the virus particle since no concomitant protein synthesis is required. T7 mutants carrying...

    Helmut Ponta, Karl-Heinz Altendorf, Manfred Schweiger in Molecular and General Genetics MGG (1976)

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    Article

    Correlation between structural variation and activity of murine kidney β-galactosidase: Implications for genetic control

    Two closely linked regulatory genes have been reported to control activity levels of β-galactosidases in murine tissues. The specific effects of these genes on murine glycolipid metabolism have not been elucid...

    I. C. Li, W. L. Daniel in Biochemical Genetics (1976)

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    Article

    Early T7 gene expression

    The mode of transcription of early T7 genes starting from one promotor region and generating a unique polycistronic RNA species suggests the appearance of equimolar amounts of the monocistronic species after R...

    Mei-li Pfennig-Yeh, Helmut Ponta in Molecular and General Genetics MGG (1978)

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    Article

    The half-life of mRNA in Saccharomyces cerevisiae

    The decay kinetics of mRNA was studied in a yeast temperature-sensitive mutant, ts136, which is defective in cytoplasmic RNA production at 37° C. The disappearance of the synthetic capacity of mRNA was determined...

    Li-Li Chia, Calvin McLaughlin in Molecular and General Genetics MGG (1979)

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    Article

    Radiation sensitivity of messenger RNA

    Messenger RNA function is inactivated by irradiation with ultraviolet light. A unit length mRNA (in bases) is 2–3 times more sensitive than a unit length of DNA (in base pairs) with respect to the inactivation...

    Helmut Ponta, Mei-Li Pfennig-Yeh, Erwin F. Wagner in Molecular and General Genetics MGG (1979)

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    Article

    Structural relatedness of mouse lactate dehydrogenase isozymes, A4 (muscle), B4 (heart), and C4 (testis)

    Three homotetrameric lactate dehydrogenase isozymes, LDH-M(A4), LDH-H(B4), and LDH-X(C4), from DBA/2J mice have been purified by affinity chromatography. The amino acid compositions of the subunits A, B, and C, b...

    Shou-Mei T. Chang, Chi-Yu Lee, Steven S.-L. Li in Biochemical Genetics (1979)

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    Article

    Nitrogen regulation of uricase synthesis in Neurospora crassa

    Neurospora crassa can utilize various purine bases as a nitrogen source. Synthesis of the purine catabolic enzymes such as uricase requires induction by the intermediate uric acid and is also subject to nitrogen...

    Li-Wen C. Wang, George A. Marzluf in Molecular and General Genetics MGG (1979)

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    Article

    Evidence for the transcription of physiologically inactive rat-liver nucleolar chromatin byEscherichia coli RNA polymerase

    Rat-liver nucleoli (10-15 pg DNA) were digested with either 0.6 or 3 units of DNase I for various times (up to 1 h). RNA synthesis was then measured in the absence or presence ol 3 units ofEscherichia coli RNA po...

    Fu-Li Yu, Annabella Barrett in Bioscience Reports (1982)

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    Article

    Human liver alcohol dehydrogenase: ADHIndianapolis results from genetic polymorphism at the ADH 2 gene locus

    New molecular forms of human liver alcohol dehydrogenase (ADH), collectively designated ADHIndianapolis (ADHInd), were recently discovered in 29% of liver specimens from Black Americans [Bosron, W. F., Li, T.-K.,...

    William F. Bosron, Leslie J. Magnes, Ting-Kai Li in Biochemical Genetics (1983)

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    Article

    Polymorphism of human liver alcohol dehydrogenase: Identification of ADH2 2-1 and ADH2 2-2 phenotypes in the Japanese by isoelectric focusing

    Liver homogenate-supernatants from most Japanese exhibit an “atypical” pH optimum for ethanol oxidation at pH 8.8 instead of 10.5, the “typical” pH-activity optimum. It has been proposed that atypical livers cont...

    S. -J. Yin, W. F. Bosron, T. -K. Li, K. Ohnishi, K. Okuda, H. Ishii in Biochemical Genetics (1984)

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    Article

    Purification and characterization of mouse alcohol dehydrogenase from two inbred strains that differ in total liver enzyme activity

    Alcohol dehydrogenase activity in mouse liver homogenate-supernatants is 1.7 times greater in the C57BL/10 strain than in the BALB/c strain, regardless of whether activity is expressed in units per gram liver,...

    Douglas K. Rex, William F. Bosron, Ting-Kai Li in Biochemical Genetics (1984)

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    Article

    Pleiotropic mutants of Chinese hamster cells with altered cytidine 5′-triphosphate synthetase

    Following chemical mutagenesis and multiple-step indirect selection, four clones of Chinese hamster V79 cells were isolated which exhibited auxotrophy for thymidine, deoxycytidine, or deoxyuridine but not for ...

    Ernest H. Y. Chu, John D. McLaren, I-Chian Li, Barbara Lamb in Biochemical Genetics (1984)

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    Article

    Suppression of defective-sporulation phenotypes by mutations in the major sigma factor gene (rpoD) of Bacillus subtilis

    Mutations (crsA47 and crsA4) in the major sigma factor gene (rpoD) of Bacillus subtilis RNA polymerase have been found to be powerful intergenic suppressors of spoOB, spoOE, spoOF, spoOK and spoIIG mutations. The...

    Abraham Leung, Sheryl Rubinstein, Charles Yang in Molecular and General Genetics MGG (1985)

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    Article

    Genetically determined differences in liver alcohol dehydrogenase activity in male rats

    Alcohol dehydrogenase (EC 1.1.1.1) activity was measured in liver extracts from one outbred and three inbred strains of rats. Strain-specific differences in enzyme activity were observed in the adult male rats...

    David W. Crabb, Ting-Kai Li in Biochemical Genetics (1985)

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    Article

    Gene map** on human metaphase chromosomes by in situ hybridization with 3H, 35S, and 32P labeled probes and transmission electron microscopy

    A method based on in situ hybridization, autoradiography and transmission electron microscopy for map** genes on human metaphase chromosomes is presented. Successful map** of the tandemly repeated rDNA gen...

    Chang-ben Li, Madeline Wu, Irene S. Margitich, Norman Davidson in Chromosoma (1986)

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