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507 Result(s)
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Article
SenNet recommendations for detecting senescent cells in different tissues
Once considered a tissue culture-specific phenomenon, cellular senescence has now been linked to various biological processes with both beneficial and detrimental roles in humans, rodents and other species. Mu...
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Roles and regulation of tRNA-derived small RNAs in animals
A growing class of small RNAs, known as tRNA-derived RNAs (tdRs), tRNA-derived small RNAs or tRNA-derived fragments, have long been considered mere intermediates of tRNA degradation. These small RNAs have rece...
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Regulation and functions of non-m6A mRNA modifications
Nucleobase modifications are prevalent in eukaryotic mRNA and their discovery has resulted in the emergence of epitranscriptomics as a research field. The most abundant internal (non-cap) mRNA modification is N6-...
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Open AccessDifferential transcriptomic landscapes of multiple organs from SARS-CoV-2 early infected rhesus macaques
SARS-CoV-2 infection causes complicated clinical manifestations with variable multi-organ injuries, however, the underlying mechanism, in particular immune responses in different organs, remains elusive. In th...
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Open AccessCorrection to: Gonadal mosaicism mediated female-biased gender control in mice
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Open AccessEfficient expansion of rare human circulating hematopoietic stem/progenitor cells in steady-state blood using a polypeptide-forming 3D culture
Although widely applied in treating hematopoietic malignancies, transplantation of hematopoietic stem/progenitor cells (HSPCs) is impeded by HSPC shortage. Whether circulating HSPCs (cHSPCs) in steady-state bl...
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Open AccessPostnatal state transition of cardiomyocyte as a primary step in heart maturation
Postnatal heart maturation is the basis of normal cardiac function and provides critical insights into heart repair and regenerative medicine. While static snapshots of the maturing heart have provided much in...
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Open AccessTsai Chiao: The founder of physiology and aviation, aerospace and navigation medicine in China
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Open AccessGonadal mosaicism mediated female-biased gender control in mice
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Open AccessCorrection to: Novel and potent inhibitors targeting DHODH are broad-spectrum antivirals against RNA viruses including newly-emerged coronavirus SARS-CoV-2
In the original publication the author’s name ‘Dimitri Lavillete’ is published incorrectly. The correct author name should be spelt as ‘Dimitri Lavillette’ is provided in this correction.
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Open AccessNew pathogenic insights from large animal models of neurodegenerative diseases
Animal models are essential for investigating the pathogenesis and develo** the treatment of human diseases. Identification of genetic mutations responsible for neurodegenerative diseases has enabled the cre...
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Open AccessDarwinian rebel: The legacy of Loh-Seng Tsai—Chinese animal psychologist
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Open AccessModeling hepatoblastoma development with human fetal liver organoids reveals YAP1 activation is sufficient for tumorigenesis
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Open AccessAn ultrapotent pan-β-coronavirus lineage B (β-CoV-B) neutralizing antibody locks the receptor-binding domain in closed conformation by targeting its conserved epitope
New threats posed by the emerging circulating variants of SARS-CoV-2 highlight the need to find conserved neutralizing epitopes for therapeutic antibodies and efficient vaccine design. Here, we identified a re...
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Open AccessSARS-CoV-2 impairs the disassembly of stress granules and promotes ALS-associated amyloid aggregation
The nucleocapsid (N) protein of SARS-CoV-2 has been reported to have a high ability of liquid-liquid phase separation, which enables its incorporation into stress granules (SGs) of host cells. However, whether...
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Open AccessHyperthermia differentially affects specific human stem cells and their differentiated derivatives
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Open AccessLegacy of Hongxi Su: Pioneer of Chinese Cardiosurgery
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Open AccessBMP4 preserves the developmental potential of mESCs through Ube2s- and Chmp4b-mediated chromosomal stability safeguarding
Chemically defined medium is widely used for culturing mouse embryonic stem cells (mESCs), in which N2B27 works as a substitution for serum, and GSK3β and MEK inhibitors (2i) help to promote ground-state pluri...
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Sources, resolution and physiological relevance of R-loops and RNA–DNA hybrids
RNA–DNA hybrids are generated during transcription, DNA replication and DNA repair and are crucial intermediates in these processes. When RNA–DNA hybrids are stably formed in double-stranded DNA, they displace...
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Open AccessLIN28 coordinately promotes nucleolar/ribosomal functions and represses the 2C-like transcriptional program in pluripotent stem cells
LIN28 is an RNA binding protein with important roles in early embryo development, stem cell differentiation/reprogramming, tumorigenesis and metabolism. Previous studies have focused mainly on its role in the ...