10 Result(s)
within
Life Sciences
Biochemistry, general
Human Genetics
Plant Sciences
Lu**g Li
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Chapter
Two-Dimensional Gene Scanning
The large size of many human genes, in combination with the frequent occurrence of many different mutations over the entire gene, severely limits direct diagnosis. Since gene diagnosis by sequencing on a large...
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Chapter
Structure-Activity Relationship of the Agonist-Antagonist Transition on the Type 1 Angiotensin II Receptor; the Search for Inverse Agonists
Peptidic angiotensin II (Ang) antagonists have been mostly reported to behave in a more or less competitive fashion. Thus, reinforcing the view of competitive analogues being compounds which can reversibly bin...
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Chapter
Neurotransmitter-Gated Ion Channels as Molecular Sites of Alcohol Action
The mechanism of alcohol action in the nervous system has long been a subject of great interest. Almost a century ago, two German scientists, Overton (1896; 1901) and Meyer (1899; 1901), found a correlation be...
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Chapter
Functional Aspects of Three Modified Nucleosides, Ψ, ms2io6A, and m1G, Present in the Anticodon Loop of tRNA
Transfer RNAs contain many modified nucleosides, which are derivatives of the four normal nucleosides. At present more than 75 different modified nucleosides are characterised (Edmonds et al., 1991). The synthesi...
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Chapter
Susceptibility of Dark Chlorophyll Synthesis in Barley and Pine Seedlings to Inhibition by Gabaculine
Dark chlorophyll accumulation in pine (Pinus pinea and Pinus nigra) and barley (Hordeum vulgare) seedlings was inhibited by gabaculine (3-amino 2,3-dihydrobenzoic acid) (GAB). The inhibitory effect of GAB was ove...
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Chapter
Targeting of Proteins into and Across the Chloroplastic Envelope
Chloroplasts are functionally complex organelles that perform a diverse array of metabolic processes in addition to their well known role in photosynthesis. Consistent with their functional complexity, chlorop...
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Chapter
Substrate Specificity Study of Recombinant Rhizopus Chinensis Aspartic Proteinase
Rhizopuspepsin, a model aspartic proteinase from the fungus Rhizopus chinensis, has recently been cloned and expressed by Chen et al. (1991). High resolution crystallographic analysis of rhizopuspepsin and comple...
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Exploiting the Molecular Template of Angiotensinogen in the Discovery and Design of Peptidyl, Pseudopeptidyl and Peptidemimetic Inhibitors of Human Renin: A Structure-Activity Perspective
The design of potent and pharmacologically effective, substrate-related inhibitors of renin has been the subject of intensive pharmaceutical discovery research for about one decade. Milestone achievements in s...
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Chapter
Future Directions in Biomedical Research on Alcoholism
This book is based on the proceedings of the NATO Advanced Study Institute (ASI) on ‘The Molecular Pathology of Alcoholism’ held at Il Ciocco in Italy on August 26th -September 6th 1990. An important part of t...
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Structure and Function of the Maize Transposable Element Activator (AC)
The discovery of transposable elements in maize by Barbara McClintock was greatly facilitated by the thorough genetic characterization of this species since the early years of this century. In particular, the ...
