30 Result(s)
within
Life Sciences
Biochemistry, general
Eukaryotic Microbiology
Human Genetics
Lu**g Li
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Article
The regulation of Tfh cell differentiation by β-hydroxybutyrylation modification of transcription factor Bcl6
Transcriptional repressor B cell lymphoma 6 (Bcl6) is a major transcription factor involved in Tfh cell differentiation and germinal center response, which is regulated by a variety of biological processes. Ho...
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Article
Open AccessImaging assay to probe the role of telomere length shortening on telomere-gene interactions in single cells
Telomeres are repetitive non-coding nucleotide sequences (TTAGGGn) cap** the ends of chromosomes. Progressive telomere shortening with increasing age has been associated with shifts in gene expression throug...
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Article
Open AccessImmediate visualization of recombination events and chromosome segregation defects in fission yeast meiosis
Schizosaccharomyces pombe, also known as fission yeast, is an established model for studying chromosome biological processes. Over the years, research employing fission yeast has made important contributions to o...
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Article
Chromosome painting in meiosis reveals pairing of specific chromosomes in polyploid Solanum species
Analysis of chromosome pairing has been an important tool to assess the genetic similarity of homologous and homoeologous chromosomes in polyploids. However, it is technically challenging to monitor the pairin...
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Article
Identification of all homoeologous chromosomes of newly synthetic allotetraploid Cucumis × hytivus and its wild parent reveals stable subgenome structure
Allopolyploidy and homoeologous recombination are two important processes in resha** genomes and generating evolutionary novelties. Newly formed allopolyploids usually display chromosomal perturbations as a ...
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Article
Erratum to: Unique sequence organization and small RNA expression of a “selfish” B chromosome
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Article
Unique sequence organization and small RNA expression of a “selfish” B chromosome
B chromosomes are found in numerous plants and animals. These nonessential, supernumerary chromosomes are often composed primarily of noncoding DNA repeats similar to those found within transcriptionally “sile...
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Article
The ISWI remodeler in plants: protein complexes, biochemical functions, and developmental roles
Imitation Switch (ISWI) is a member of the ATP-dependent chromatin remodeling factor family, whose members move or restructure nucleosomes using energy derived from ATP hydrolysis. ISWI proteins are conserved ...
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Article
Histone H3S10 phosphorylation by the JIL-1 kinase in pericentric heterochromatin and on the fourth chromosome creates a composite H3S10phK9me2 epigenetic mark
The JIL-1 kinase mainly localizes to euchromatic interband regions of polytene chromosomes and is the kinase responsible for histone H3S10 phosphorylation at interphase in Drosophila. However, recent findings rai...
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Article
Homoeologous relationship of rye chromosome arms as detected with wheat PLUG markers
Based on the similarity in gene structure between rice and wheat, the polymerase chain reaction (PCR)-based landmark unique gene (PLUG) system enabled us to design primer sets that amplify wheat genic sequence...
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Article
MRE11 is required for homologous synapsis and DSB processing in rice meiosis
Mre11, a conserved protein found in organisms ranging from yeast to multicellular organisms, is required for normal meiotic recombination. Mre11 interacts with Rad50 and Nbs1/Xrs2 to form a complex (MRN/X) tha...
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Article
A novel translocation event leads to a recombinant stable chromosome with interrupted centromeric domains in rice
Rice (Oryza sativa L.) centromeres are composed of 155-bp satellite repeats (CentO), centromere-specific retrotransposon (CRR), and a variety of other repeats. Previous studies have shown that CentO and CRR eleme...
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Article
Epigenetic regulation of genomic integrity
Inefficient and inaccurate repair of DNA damage is the principal cause of DNA mutations, chromosomal aberrations, and carcinogenesis. Numerous multiple-step DNA repair pathways exist whose deployment depends o...
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Article
Double-strand breaks and the concept of short- and long-term epigenetic memory
Double-strand breaks represent an extremely cytolethal form of DNA damage and thus pose a serious threat to the preservation of genetic and epigenetic information. Though it is well-known that double-strand br...
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Article
Structure and dynamics of retrotransposons at wheat centromeres and pericentromeres
Little is known of the dynamics of centromeric DNA in polyploid plants. We report the sequences of two centromere-associated bacterial artificial chromosome clones from a Triticum boeoticum library. Both autonomo...
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Article
Fluorescence in situ hybridization (FISH) on maize metaphase chromosomes with quantum dot-labeled DNA conjugates
Semiconductor nanocrystals, also called quantum dots (QDs), are novel inorganic fluorophores which are brighter and more photostable than organic fluorophores. In the present study, highly dispersive QD-labele...
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Article
Association of cohesin and Nipped-B with transcriptionally active regions of the Drosophila melanogaster genome
The cohesin complex is a chromosomal component required for sister chromatid cohesion that is conserved from yeast to man. The similarly conserved Nipped-B protein is needed for cohesin to bind to chromosomes....
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Article
Cell-type specific proximity of centromeric domains of one homologue each of chromosomes 2 and 11 in nuclei of cerebellar Purkinje neurons
In Purkinje neurons of the mouse cerebellum, the centromeres of several chromosomes are placed in close proximity to form a distinct pattern of clusters and exhibit reproducible spatial redistributions during ...
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Article
Karyotypic evolution of a novel cervid satellite DNA family isolated by microdissection from the Indian muntjac Y-chromosome
A minilibrary was constructed from DOP-PCR products using microdissected Y-chromosomes of Indian muntjac as DNA templates. Two microclones designated as IM-Y4-52 and IM-Y5-7 were obtained from negative screeni...
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Article
A new chromosome fluorescence banding technique combining DAPI staining with image analysis in plants
In this study, a new chromosome fluorescence banding technique was developed in plants. The technique combined 4′,6-diamidino-2-phenylindole (DAPI) staining with software analysis including three-dimensional i...
