3 Result(s)
within
Louise J. Eltringham-Smith
Chemistry
Biochemical Engineering
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Article
Open AccessAddition of a sequence from α2-antiplasmin transforms human serum albumin into a blood clot component that speeds clot lysis
The plasma protein α2-antiplasmin (α2AP) is cross-linked to fibrin in blood clots by the transglutaminase factor XIIIa, and in that location retards clot lysis. Competition for this effect could be clinically use...
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Article
Open AccessIncorporation of albumin fusion proteins into fibrin clots in vitro and in vivo: comparison of different fusion motifs recognized by factor XIIIa
The transglutaminase activated factor XIII (FXIIIa) acts to strengthen pathological fibrin clots and to slow their dissolution, in part by crosslinking active α2-antiplasmin (α2AP) to fibrin. We previously report...
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Article
Open AccessA factor XIa-activatable hirudin-albumin fusion protein reduces thrombosis in mice without promoting blood loss
Hirudin is a potent thrombin inhibitor but its antithrombotic properties are offset by bleeding side-effects. Because hirudin’s N-terminus must engage thrombin’s active site for effective inhibition, fusing a ...
