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  1. Article

    Open Access

    Optimizing Nanopore sequencing-based detection of structural variants enables individualized circulating tumor DNA-based disease monitoring in cancer patients

    Here, we describe a novel approach for rapid discovery of a set of tumor-specific genomic structural variants (SVs), based on a combination of low coverage cancer genome sequencing using Oxford Nanopore with a...

    Jose Espejo Valle-Inclan, Christina Stangl, Anouk C. de Jong in Genome Medicine (2021)

  2. Article

    Open Access

    Detection of tumor-derived extracellular vesicles in plasma from patients with solid cancer

    Extracellular vesicles (EVs) are actively secreted by cells into body fluids and contain nucleic acids of the cells they originate from. The goal of this study was to detect circulating tumor-derived EVs (ctEV...

    Silvia R. Vitale, Jean A. Helmijr, Marjolein Gerritsen, Hicret Coban in BMC Cancer (2021)