-
Article
Antiviral activity of Arbidol against Coxsackie virus B5 in vitro and in vivo
We investigated the antiviral activity of Arbidol, an antiviral chemical compound, against Coxsackie virus B5 (CVB5) in vitro and in vivo. Arbidol not only prevented the cytopathic effect (CPE) of CVB5, as demons...
-
Article
Open AccessAnti-tumor effects of CIK combined with oxaliplatin in human oxaliplatin-resistant gastric cancer cells in vivo and in vitro
Drug resistance remains a great challenge in the treatment of gastric cancer. The goal of this study was to explore the anti-tumor effects and mechanism of cytokine-induced killer (CIK) cell combined with oxal...
-
Article
Open AccessAntiviral effects against EV71 of pimprinine and its derivatives isolated from Streptomyces sp
The pimprinine family of compounds represent very important and promising microbial metabolites for drug discovery. However, their ability in inhibiting viral infections has not yet been tested.
-
Article
Novonestmycins A and B, two new 32-membered bioactive macrolides from Streptomyces phytohabitans HBERC-20821
Two new 32-membered macrolide compounds, named Novonestmycins A (1) and B (2), were isolated from the soil strain Streptomyces phytohabitans HBERC-20821. Their structures were elucidated by using spectroscopic me...
-
Article
Open AccessA C-terminally truncated mouse Best3 splice variant targets and alters the ion balance in lysosome-endosome hybrids and the endoplasmic reticulum
The Bestrophin family has been characterized as Cl− channels in mammals and Na+ channels in bacteria, but their exact physiological roles remian unknown. In this study, a natural C-terminally truncated variant of...
-
Article
Open AccessThe short-term effects of air pollutants on respiratory disease mortality in Wuhan, China: comparison of time-series and case-crossover analyses
Few studies have compared different methods when exploring the short-term effects of air pollutants on respiratory disease mortality in Wuhan, China. This study assesses the association between air pollutants ...
-
Article
Open AccessMagnetic Fano resonances by design in symmetry broken THz meta-foils
Magnetic Fano resonances in there-dimensional symmetry broken meta-foils at THz frequencies are theoretically and experimentally studied. Sharp Fano resonances occur due to the interference between different r...
-
Article
Open AccessSteroidal[17,16-d]pyrimidines derived from dehydroepiandrosterone: A convenient synthesis, antiproliferation activity, structure-activity relationships, and role of heterocyclic moiety
A series of steroidal[17,16-d]pyrimidines derived from dehydroepiandrosterone were designed and prepared by a convenient heterocyclization reaction. The in vitro anticancer activities for these obtained compounds...
-
Article
Open AccessBi-layer Channel AZO/ZnO Thin Film Transistors Fabricated by Atomic Layer Deposition Technique
This letter demonstrates bi-layer channel Al-doped ZnO/ZnO thin film transistors (AZO/ZnO TFTs) via atomic layer deposition process at a relatively low temperature. The effects of annealing in oxygen atmospher...
-
Article
Open AccessHyperbolic spoof plasmonic metasurfaces
Hyperbolic metasurfaces have recently emerged as a new research frontier because of the unprecedented capabilities to manipulate surface plasmon polaritons (SPPs) and many potential applications. However, thus...
-
Article
Open AccessNicotinamide-based diamides derivatives as potential cytotoxic agents: synthesis and biological evaluation
A series of diamides derivatives containing nicotinamide unit were designed, synthesized and evaluated for their potential cytotoxic activities against human cancer cell lines. All the synthesized compounds we...
-
Article
Open AccessOptimization of a MT1-MMP-targeting Peptide and Its Application in Near-infrared Fluorescence Tumor Imaging
Membrane type 1 metalloproteinase (MT1-MMP) is an important regulator of cancer invasion, growth and angiogenesis, thus making it an attractive target for cancer imaging and therapy. A non-substrate peptide (M...
-
Article
Open AccessThe energy and mass balance of a continental glacier: Dongkemadi Glacier in central Tibetan Plateau
Understanding glacier mass balance (MB) change under global warming is important to assess the impact of glacier change on water resources. This study evaluated the applicability of a modified distributed surf...
-
Article
Open AccessKirigami metamaterials for reconfigurable toroidal circular dichroism
The ancient paper craft of kirigami has recently emerged as a potential tool for the design of functional materials. Inspired by the kirigami concept, we propose a class of kirigami-based metamaterials whose e...
-
Article
Open AccessUPF1 inhibits the hepatocellular carcinoma progression by targeting long non-coding RNA UCA1
Hepatocellular carcinoma (HCC) is one of the major causes of cancer-related death worldwide. However, the molecular mechanism underlying HCC carcinogenesis remains to be further elucidated. Up-frameshift prote...
-
Article
Open AccessDetermination of serum 25-hydroxyvitamin D status among population in southern China by a high accuracy LC-MS/MS method traced to reference measurement procedure
We aimed to describe the 25-hydroxyvitamin D (25(OH)D) status of southern Chinese individuals by a high-accuracy liquid chromatography tandem mass spectrometry (LC-MS/MS) method which can trace to reference me...
-
Article
Open AccessRNF180 mediates STAT3 activity by regulating the expression of RhoC via the proteasomal pathway in gastric cancer cells
Ring finger protein 180 (RNF180) is an important member of the E3 ubiquitin ligase family. As a tumor suppressor gene, RNF180 is significantly associated with the prognosis of patients with gastric cancer (GC)...
-
Article
Open AccessCorrection to: Determination of serum 25-hydroxyvitamin D status among population in southern China by a high accuracy LC-MS/MS method traced to reference measurement procedure
An amendment to this paper has been published and can be accessed via the original article.
-
Article
Open AccessThe apheresis platelet donation was increased after a nationwide ban on family/replacement donation in China
A nationwide ban on family/replacement donation (FRD) went into effect on April 1, 2018 in China. To date, no reports relevant to the trend of plateletpheresis donations before and after a nationwide ban on FR...
-
Article
Open AccessDNMT3A-mediated silence in ADAMTS9 expression is restored by RNF180 to inhibit viability and motility in gastric cancer cells
ADAMTS9 belongs to the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family, and its expression is frequently silenced due to promoter hypermethylation in various human cancer...
