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  1. Article

    Open Access

    Gut microbiota-host lipid crosstalk in Alzheimer’s disease: implications for disease progression and therapeutics

    Trillions of intestinal bacteria in the human body undergo dynamic transformations in response to physiological and pathological changes. Alterations in their composition and metabolites collectively contribut...

    Ya-** Luo, Ling-Ling Yang, **u-Qing Yao in Molecular Neurodegeneration (2024)

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  2. Article

    2-(3-Benzoylthioureido)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylic acid ameliorates metabolic disorders in high-fat diet-fed mice

    Sterol-regulatory element binding proteins (SREBPs) are major transcription factors that regulate liver lipid biosynthesis. In this article we reported a novel synthetic compound 2-(3-benzoylthioureido)-4,5,6,...

    ** Zhang, Li-na Zhang, Dong-mei Chen, Yan-yun Fu, Feng Zhang… in Acta Pharmacologica Sinica (2015)

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  3. Article

    Open Access

    In vitro study of the tocolytic effect of oroxylin A from Scutellaria baicalensis root

    Scutellariae Radix is one of the well-known tocolytic Chinese herbs. Oroxylin A is isolated from the root of Scutellaria baicalensis. The main syndrome of preterm birth is caused by uterus contractions from excit...

    Huey-Chuan Shih, Chun-Sen Hsu, Ling-Ling Yang in Journal of Biomedical Science (2009)

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  4. No Access

    Chapter and Conference Paper

    Mechanism of Neuroprotective Function of Taurine

    Taurine has potent protective function against glutamate-induced neuronal injury presumably through its function in regulation of intracellular free calcium level, [Ca2+]i. In this communication, we report that t...

    Jang-Yen Wu, Heng Wu, Ying **, Jianning Wei, Di Sha, Howard Prentice… in Taurine 7 (2009)

  5. No Access

    Article

    Neuroprotection and free radical scavenging effects of Osmanthus fragrans

    The ethanol extract of dried flowers Osmanthus fragrans (OFE) was assessed for free radical scavenging effects measured by the bleaching of the 1,1-diphenyl-2-picryl-hydrazyl (DPPH) radical, scavenging of the hyd...

    Hsin-Hsueh Lee, Chi-Ting Lin, Ling-Ling Yang in Journal of Biomedical Science (2007)

  6. No Access

    Article

    Wogonin and fisetin induction of apoptosis through activation of caspase 3 cascade and alternative expression of p21 protein in hepatocellular carcinoma cells SK-HEP-1

    Wogonin and fisetin are flavonoids, which are widely distributed in plants. Our recent study demonstrated that, among seven structurally related flavonoids, wogonin and fisetin showed the most potent apoptosi...

    Yen-Chou Chen, Shing-Chuan Shen, Woan-Rouh Lee, Hui-Yi Lin… in Archives of Toxicology (2002)