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Article
Open AccessModified Retzius-sparing robot-assisted radical prostatectomy for cases with anterior tumor: a propensity score-matched analysis
To compare the outcomes between a modified Retzius-sparing robot-assisted radical prostatectomy (mRS-RARP) technique and conventional robot-assisted radical prostatectomy (Con-RARP) technique for cases with an...
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Article
Open AccessRemodelling of tumour microenvironment by microwave ablation potentiates immunotherapy of AXL-specific CAR T cells against non-small cell lung cancer
The complex immunosuppressive tumour microenvironment (TME) and lack of tumour-specific targets hinder the application of chimeric antigen receptor (CAR) T cells in the treatment of solid tumours. Combining lo...
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Article
Open AccessModified biochar: synthesis and mechanism for removal of environmental heavy metals
With social progress and industrial development, heavy metal pollution in water and soils environment is becoming more serious. Although biochar is a low-cost and environmentally friendly adsorbent for heavy m...
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Article
Open AccessEngineered Bacillus subtilis for the de novo production of 2′-fucosyllactose
The most abundant human milk oligosaccharide in breast milk, 2′-fucosyllactose (2′-FL), has been approved as an additive to infant formula due to its multifarious nutraceutical and pharmaceutical functions in ...
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Article
Open AccessMap** enzyme catalysis with metabolic biosensing
Enzymes are represented across a vast space of protein sequences and structural forms and have activities that far exceed the best chemical catalysts; however, engineering them to have novel or enhanced activi...
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Article
Open AccessIL-7 and CCL19-secreting CAR-T cell therapy for tumors with positive glypican-3 or mesothelin
Although chimeric antigen receptor (CAR)-engineered T cells have shown great success in the treatment of B cell malignancies, this strategy has limited efficacy in patients with solid tumors. In mouse CAR-T ce...
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Article
Open AccessAre tumor-associated micro-angiogenesis and lymphangiogenesis considered as the novel prognostic factors for patients with Xp11.2 translocation renal cell carcinoma?
Tumor micro-angiogenesis and lymphangiogenesis are effective prognostic predictors in many solid malignancies. However, its role on Xp11.2 translocation RCC has not been fully elucidated. Herein, we purposed t...
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Article
Open AccessThe suitability of NONO-TFE3 dual-fusion FISH assay as a diagnostic tool for NONO-TFE3 renal cell carcinoma
NONO-TFE3 RCC is a subtype of Xp11.2 translocation renal cell carcinoma (RCC). So far, only a small amount of NONO-TFE3 RCC have been reported owing to lack of effective diagnosis methods. Utilizing the novel dua...
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Article
Open AccessInternal cross-linked polymeric nanoparticles with dual sensitivity for combination therapy of muscle-invasive bladder cancer
Chemotherapy is a standard cancer treatment which uses anti-cancer drugs to destroy or slow the growth of cancer cells. However, chemotherapy has limited therapeutic effects in bladder cancer. One of the reaso...
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Article
Open AccessComparative Clinicopathologic Characteristics and Outcomes of Paediatric and Adult Xp11 Translocation Renal Cell Carcinomas: a Retrospective Multicentre Study in China
This study aimed to compare the clinicopathologic features and prognosis in patients with Xp11 translocation renal cell carcinomas (RCCs). In total, 8083 RCCs were screened at five centres from January 2007 to...
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Article
Open AccessGambogenic acid inhibits fibroblast growth factor receptor signaling pathway in erlotinib-resistant non-small-cell lung cancer and suppresses patient-derived xenograft growth
Erlotinib resistance causes a high degree of lethality in non-small-cell lung cancer (NSCLC) patients. The high expression and activation of several receptor tyrosine kinases, such as JAK/STAT3, c-Met, and EGF...
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Article
Open AccessLiposome encapsulated perfluorohexane enhances radiotherapy in mice without additional oxygen supply
To investigate the effect of perfluorochemical preparations in enhancing radiotherapy, perfluocarbon nanoparticles were by encapsulating perfluorohexane into liposome [lip(PFH)].
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Article
Open AccessPercutaneous radiofrequency ablation with contrast-enhanced ultrasonography for solitary and sporadic renal cell carcinoma in patients with autosomal dominant polycystic kidney disease
The aim of this study was to assess the functional and oncologic outcomes of percutaneous radiofrequency ablation (RFA) with contrast-enhanced ultrasonography (CEUS) for renal cell carcinoma in patient with au...
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Article
Open AccessXp11.2 translocation renal cell carcinomas in young adults
Little is known about the biological behavior of Xp11.2 translocation renal cell carcinomas (RCCs) as few clinical studies have been performed using a large sample size.
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Article
Open AccessSaliency detection in complex scenes
Detecting multiple salient objects in complex scenes is a challenging task. In this paper, we present a novel method to detect salient objects in images. The proposed method is based on the general ‘center-sur...
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Article
Open AccessA unified framework for spatiotemporal salient region detection
This article presents a new bottom-up framework for spatiotemporal salient region detection. The generated saliency map can uniformly highlight the salient regions. In the proposed framework, the spatial visua...
