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  1. Article

    Open Access

    Remodelling of tumour microenvironment by microwave ablation potentiates immunotherapy of AXL-specific CAR T cells against non-small cell lung cancer

    The complex immunosuppressive tumour microenvironment (TME) and lack of tumour-specific targets hinder the application of chimeric antigen receptor (CAR) T cells in the treatment of solid tumours. Combining lo...

    Bihui Cao, Manting Liu, Lu Wang, Kangshun Zhu, Mingyue Cai in Nature Communications (2022)

  2. Article

    Open Access

    Map** enzyme catalysis with metabolic biosensing

    Enzymes are represented across a vast space of protein sequences and structural forms and have activities that far exceed the best chemical catalysts; however, engineering them to have novel or enhanced activi...

    Linfeng Xu, Kai-Chun Chang, Emory M. Payne, Cyrus Modavi in Nature Communications (2021)

  3. Article

    Open Access

    The suitability of NONO-TFE3 dual-fusion FISH assay as a diagnostic tool for NONO-TFE3 renal cell carcinoma

    NONO-TFE3 RCC is a subtype of Xp11.2 translocation renal cell carcinoma (RCC). So far, only a small amount of NONO-TFE3 RCC have been reported owing to lack of effective diagnosis methods. Utilizing the novel dua...

    Ning Liu, Wei Guo, Qiancheng Shi, Wenyuan Zhuang, **aohong Pu in Scientific Reports (2020)

  4. Article

    Open Access

    Comparative Clinicopathologic Characteristics and Outcomes of Paediatric and Adult Xp11 Translocation Renal Cell Carcinomas: a Retrospective Multicentre Study in China

    This study aimed to compare the clinicopathologic features and prognosis in patients with Xp11 translocation renal cell carcinomas (RCCs). In total, 8083 RCCs were screened at five centres from January 2007 to...

    Wenliang Ma, Ning Liu, Wenyuan Zhuang, Weijian Li, Feng Qu, **g Sun in Scientific Reports (2020)