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  1. No Access

    Article

    Development of a chemical probe against NUDT15

    The NUDIX hydrolase NUDT15 was originally implicated in sanitizing oxidized nucleotides, but was later shown to hydrolyze the active thiopurine metabolites, 6-thio-(d)GTP, thereby dictating the clinical respon...

    Si Min Zhang, Matthieu Desroses, Anna Hagenkort… in Nature Chemical Biology (2020)

  2. Article

    Open Access

    AXL and CAV-1 play a role for MTH1 inhibitor TH1579 sensitivity in cutaneous malignant melanoma

    Cutaneous malignant melanoma (CMM) is the deadliest form of skin cancer and clinically challenging due to its propensity to develop therapy resistance. Reactive oxygen species (ROS) can induce DNA damage and p...

    Ishani Das, Helge Gad, Lars Bräutigam, Linda Pudelko… in Cell Death & Differentiation (2020)

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