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Article
Open AccessThe Effect of Lens Shape, Zonular Insertion and Finite Element Model on Simulated Shape Change of the Eye Lens
The process of lens shape change in the eye to alter focussing (accommodation) is still not fully understood. Modelling approaches have been used to complement experimental findings in order to determine how c...
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Article
Open AccessDifferences of clinical phenotype between familial and sporadic Crohn’s disease in East China
Family history is one of the strongest risk factors for inflammatory bowel diseases (IBD) while studies about the clinical phenotype of familial IBD are limited. This study aimed to compare the phenotypic feat...
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Article
Open AccessEffects of key process parameters on tensile properties and interlayer bonding behavior of 3D printed PLA using fused filament fabrication
Fused Filament Fabrication (FFF), also known as Fused Deposition Modelling (FDM), is one of the innovative 3D printing technologies for fabricating complex components and products. Mechanical properties of 3D-...
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Article
Open AccessLeukocyte immunoglobulin-like receptor B1 (LILRB1) protects human multiple myeloma cells from ferroptosis by maintaining cholesterol homeostasis
Multiple myeloma (MM) is a hematologic malignancy characterized by uncontrolled proliferation of plasma cells in the bone marrow. MM patients with aggressive progression have poor survival, emphasizing the urg...
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Article
Open AccessClinical and Imaging Characteristics of Herlyn-Werner-Wunderlich Syndrome: a Comprehensive Analysis
To describe the clinical and imaging characteristics of Herlyn-Werner-Wunderlich syndrome (HWWS).
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Article
Open AccessTrajectories of positive and negative affect and state hope and their relationship with mental health among male adolescents in a juvenile correctional institution in China
Positive affect and hope contribute to individuals’ psychological adjustment and positive youth development. The purpose of the study was to examine growth in positive and negative affect as well as state hope...
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Article
Open AccessA survey of breastfeeding among women with previous surgery for benign breast disease: a descriptive exploratory study
Surgery is the primary treatment for benign breast disease and causes some disruption to the normal physiology of the breast, even when this disruption is localised, it remains unclear whether it affects women...
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Article
Open AccessAn innovative cell-based transplantation therapy for an immature permanent tooth in an adult: a case report
Immature teeth with necrotic pulps present multiple challenges to clinicians. In such cases, regenerative endodontic procedures (REPs) may be a favorable strategy. Cells, biomaterial scaffolds, and signaling m...
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Open AccessCorrection: ScRNA-seq revealed an immunosuppression state and tumor microenvironment heterogeneity related to lymph node metastasis in prostate cancer
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Open AccessTumor derived exosomal ENTPD2 impair CD8+ T cell function in colon cancer through ATP-adenosine metabolism reprogramming
Extracellular ATP–AMP–adenosine metabolism plays a pivotal role in modulating tumor immune responses. Previous studies have shown that the conversion of ATP to AMP is primarily catalysed by Ectonucleoside trip...
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Article
Open AccessTranscriptomic and cellular decoding of scaffolds-induced suture mesenchyme regeneration
Precise orchestration of cell fate determination underlies the success of scaffold-based skeletal regeneration. Despite extensive studies on mineralized parenchymal tissue rebuilding, regenerating and maintain...
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Article
Open AccessProteomics study of primary and recurrent adamantinomatous craniopharyngiomas
Adamantinomatous craniopharyngiomas (ACPs) are rare benign epithelial tumours with high recurrence and poor prognosis. Biological differences between recurrent and primary ACPs that may be associated with dise...
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Article
Open AccessThiamine-modified metabolic reprogramming of human pluripotent stem cell-derived cardiomyocyte under space microgravity
During spaceflight, the cardiovascular system undergoes remarkable adaptation to microgravity and faces the risk of cardiac remodeling. Therefore, the effects and mechanisms of microgravity on cardiac morpholo...
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Article
Open AccessCold-induced FOXO1 nuclear transport aids cold survival and tissue storage
Cold-induced injuries severely limit opportunities and outcomes of hypothermic therapies and organ preservation, calling for better understanding of cold adaptation. Here, by surveying cold-altered chromatin a...
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Article
Open AccessSNP-based and haplotype-based genome-wide association on drug dependence in Han Chinese
Drug addiction is a serious problem worldwide and is influenced by genetic factors. The present study aimed to investigate the association between genetics and drug addiction among Han Chinese.
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Open AccessSwimming exercise reverses transcriptomic changes in aging mouse lens
The benefits of physical activity for the overall well-being of elderly individuals are well-established, the precise mechanisms through which exercise improves pathological changes in the aging lens have yet ...
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Article
Open AccessExpert consensus on difficulty assessment of endodontic therapy
Endodontic diseases are a kind of chronic infectious oral disease. Common endodontic treatment concepts are based on the removal of inflamed or necrotic pulp tissue and the replacement by gutta-percha. However...
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Article
Open AccessDisrupted Tuzzerella abundance and impaired l-glutamine levels induce Treg accumulation in ovarian endometriosis: a comprehensive multi-omics analysis
The microbial community plays a crucial role in the pathological microenvironment. However, the structure of the microbial community within endometriotic lesions and its impact on the microenvironment is still...
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Open AccessEfficacy and safety of direct oral anticoagulants versus low-molecular-weight heparin for thromboprophylaxis after cancer surgery: a systematic review and meta-analysis
Direct oral anticoagulants (DOACs) used as an alternative to low-molecular-weight heparin (LMWH) for thromboprophylaxis after cancer surgery for venous thromboembolic events (VTE) remains unclear. This study a...
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Open AccessResidual Contextual Hourglass Network for Single-Image Deraining
Rain streaks could blur and distort images, significantly impacting further image processing. Single-image deraining is a hotspot and has practical application value, while most existing methods still have pro...
