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Article
Protective effects of ginsenosides on ulcerative colitis: a meta-analysis and systematic review to reveal the mechanisms of action
Ulcerative colitis (UC) is a chronic inflammatory disease of the colon. Ginsenoside may be an ideal agent for UC treatment. However, its efficacy and safety are unknown. We aim to conduct a systematic evaluati...
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Article
Advancing microarray fabrication: One-pot synthesis and high-resolution patterning of UV-crosslinkable perovskite quantum dots
The development of highly efficient, solution-processable, and environmentally stable perovskite quantum dots (PQDs) is crucial for their accurate high-resolution patterning and subsequently enabling the pract...
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Article
Open AccessATP6V0A1-dependent cholesterol absorption in colorectal cancer cells triggers immunosuppressive signaling to inactivate memory CD8+ T cells
Obesity shapes anti-tumor immunity through lipid metabolism; however, the mechanisms underlying how colorectal cancer (CRC) cells utilize lipids to suppress anti-tumor immunity remain unclear. Here, we show th...
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Article
Retraction Note: Declining melatonin levels and MT1 receptor expression in aging rats is associated with enhanced mammary tumor growth and decreased sensitivity to melatonin
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Article
Incidence and characteristic of deep venous thrombosis in hospitalized chronic heart failure patients
This study was conducted to investigate the incidence of deep venous thrombosis (DVT), outcomes and its characteristics in patients with chronic heart failure (CHF) in a retrospective setting.
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Article
Application of intelligent decision system based on artificial neural network in free forging of the engine main shaft
The engine main shaft forgings have high requirements for product consistency and reliability, which are difficult to be guaranteed by traditional manual free forging. On the basis of the already-in-place mach...
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Article
AKR1C2 genetic variants mediate tobacco carcinogens metabolism involving bladder cancer susceptibility
Tobacco carcinogens metabolism-related genes (TCMGs) could generate reactive metabolites of tobacco carcinogens, which subsequently contributed to multiple diseases. However, the association between genetic va...
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Article
Simplified p-i-n Perovskite Solar Cells with a Multifunctional Polyfullerene Electron Transporter
In prevailing p-i-n perovskite solar cells (PSCs), solution-processible fullerene molecules are widely used as electron-transporting layers (ETLs) but they typically suffer from poor uniformity and undesirable...
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Article
The serum LDH level and KELIM scores are potential predictors of a benefit from bevacizumab first-line therapy for patients with advanced ovarian cancer
The survival benefit of first-line treatment with bevacizumab in advanced ovarian cancer patients are multifaceted. In our study, we aimed to identify potential markers of bevacizumab efficacy to help predict ...
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Article
RGS1 Enhancer RNA Promotes Gene Transcription by Recruiting Transcription Factor FOXJ3 and Facilitates Osteoclastogenesis Through PLC-IP3R-dependent Ca2+ Response in Rheumatoid Arthritis
Recent evidence has highlighted the functions of enhancers in modulating transcriptional machinery and affecting the development of human diseases including rheumatoid arthritis (RA). Enhancer RNAs (eRNAs) are...
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Article
Open AccessDeep learning-based pathological prediction of lymph node metastasis for patient with renal cell carcinoma from primary whole slide images
Metastasis renal cell carcinoma (RCC) patients have extremely high mortality rate. A predictive model for RCC micrometastasis based on pathomics could be beneficial for clinicians to make treatment decisions.
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Article
Open AccessThe effect of different flushing and locking techniques on catheter occlusion rates in central venous catheters: protocol for a multicentre, randomized controlled, parallel-group, open-label, superiority clinical trial
Maintaining venous access is of great clinical importance. Running a slow continuous infusion to keep the vein open (KVO) is often used in peripheral intravenous catheters (PIVCs). Previous studies have compar...
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Article
Molecular mechanism of Saikosaponin-d in the treatment of gastric cancer based on network pharmacology and in vitro experimental verification
The study aimed to utilize network pharmacology combined with cell experiments to research the mechanism of action of Saikosaponin-d in the treatment of gastric cancer. Drug target genes were obtained from the...
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Article
Open AccessStructural basis of promoter recognition by Staphylococcus aureus RNA polymerase
Bacterial RNAP needs to form holoenzyme with σ factors to initiate transcription. While Staphylococcus aureus σA controls housekee** functions, S. aureus σB regulates virulence, biofilm formation, persistence, ...
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Article
Correlation Study on Grain Size Characteristics and Geotechnical Properties of Surface Sediments in Qingdao Offshore Area
The comprehension of sediment grain size parameters and the corresponding sedimentary environment holds paramount importance in elucidating the engineering geological attributes of the subaqueous seabed. This ...
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Article
Critical turbidity thresholds for maintenance of estuarine tidal flats worldwide
Tidal flats are shrinking in extent globally. The dynamics of the response of estuarine tidal flats to global environmental changes remain unclear. Tidal-flat morphology is shaped by the interplay among wave a...
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Article
Open AccessDevelopment and validation of a simple and practical model for early detection of diabetic macular edema in patients with type 2 diabetes mellitus using easily accessible systemic variables
Diabetic macular edema (DME) is the leading cause of visual impairment in patients with diabetes mellitus (DM). The goal of early detection has not yet achieved due to a lack of fast and convenient methods. Th...
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Article
Different genetic profiles contribute to worse overall survival in patients with leptomeningeal metastases of non-small-cell lung cancer
To assess the genetic characteristics of central nervous system (CNS) metastases from non-small-cell lung cancer (NSCLC), we gathered the genetic profiles of brain metastases (BM) and leptomeningeal metastases...
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Article
Open AccessCalibration of satellite typhoon data based on attitude modified buoy
To address the issue of poor accuracy in typhoon wind data, this paper presents a methodology for the calibration of typhoon wind data while conducting an analysis and evaluation of the associated uncertaintie...
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Article
Open AccessIdentification of blood exosomal metabolomic profiling for high-altitude cerebral edema
High-altitude cerebral edema (HACE) is a severe neurological condition that can occur at high altitudes. It is characterized by the accumulation of fluid in the brain, leading to a range of symptoms, including...
