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Article
Open AccessdbCNV: deleteriousness-based model to predict pathogenicity of copy number variations
Copy number variation (CNV) is a type of structural variation, which is a gain or loss event with abnormal changes in copy number. Methods to predict the pathogenicity of CNVs are required to realize the relat...
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Article
Open AccessPublisher Correction: A neural m6A/Ythdf pathway is required for learning and memory in Drosophila
A Correction to this paper has been published: https://doi.org/10.1038/s41467-021-22219-8
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Article
Open AccessA neural m6A/Ythdf pathway is required for learning and memory in Drosophila
Epitranscriptomic modifications can impact behavior. Here, we used Drosophila melanogaster to study N6-methyladenosine (m6A), the most abundant modification of mRNA. Proteomic and functional analyses confirm its ...
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Article
An advanced method for the sensitivity analysis of safety system
Safety system always involves variation on account of the epistemic uncertainty of the inputs. Therefore, it is significant to identify the uncertainty source of the output for the safety system. Sensitivity a...
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Article
Open AccessThe m6A pathway facilitates sex determination in Drosophila
The conserved modification N6-methyladenosine (m6A) modulates mRNA processing and activity. Here, we establish the Drosophila system to study the m6A pathway. We first apply miCLIP to map m6A across embryogenesis...
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Article
Ci antagonizes Hippo signaling in the somatic cells of the ovary to drive germline stem cell differentiation
Many stem cell populations are tightly regulated by their local microenvironment (niche), which comprises distinct types of stromal cells. However, little is known about mechanisms by which niche subgroups coo...
