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Article
Open AccessMachine learning-based disulfidptosis-related lncRNA signature predicts prognosis, immune infiltration and drug sensitivity in hepatocellular carcinoma
Disulfidptosis a new cell death mode, which can cause the death of Hepatocellular Carcinoma (HCC) cells. However, the significance of disulfidptosis-related Long non-coding RNAs (DRLs) in the prognosis and imm...
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Article
Open AccessOptimizing the ordering of the Hadamard masks of ghost imaging suitable for the efficient face reconstruction using the max-projection method
One crucial component of ghost imaging (GI) is the encoded mask. Higher-quality reconstruction at lower sampling rates is still a major challenge for GI. Inspired by deep learning, max-projection method is pro...
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Article
Open AccessLattice pinning in MoO3 via coherent interface with stabilized Li+ intercalation
Large lattice expansion/contraction with Li+ intercalation/deintercalation of electrode active materials results in severe structural degradation to electrodes and can negatively impact the cycle life of solid-st...
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Article
Open AccessAbnormal neonatal brain microstructure in gestational diabetes mellitus revealed by MRI texture analysis
To investigate the value of MRI texture analysis in evaluating the effect of gestational diabetes mellitus (GDM) on neonatal brain microstructure development, we retrospectively collected images of neonates un...
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Article
Open AccessSmall molecule branched-chain ketoacid dehydrogenase kinase (BDK) inhibitors with opposing effects on BDK protein levels
Branched chain amino acid (BCAA) catabolic impairments have been implicated in several diseases. Branched chain ketoacid dehydrogenase (BCKDH) controls the rate limiting step in BCAA degradation, the activity ...
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Article
Open AccessChronic UCN2 treatment desensitizes CRHR2 and improves insulin sensitivity
Urocortin 2 (UCN2) acts as a ligand for the G protein-coupled receptor corticotropin-releasing hormone receptor 2 (CRHR2). UCN2 has been reported to improve or worsen insulin sensitivity and glucose tolerance ...
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Article
Open AccessUHPLC-HRMS-based metabolomic and lipidomic characterization of glioma cells in response to anlotinib
Anlotinib, as a promising oral small-molecule antitumor drug, its role in glioma has been only reported in a small number of case reports. Therefore, anlotinib has been considered as a promising candidate in g...
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Article
Open AccessPublisher Correction: Visualizing translation dynamics at atomic detail inside a bacterial cell
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Open AccessVisualizing translation dynamics at atomic detail inside a bacterial cell
Translation is the fundamental process of protein synthesis and is catalysed by the ribosome in all living cells1. Here we use advances in cryo-electron tomography and sub-tomogram analysis2,3 to visualize the st...
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Article
Open AccessEffects of organic fertilizer proportion on the distribution of soil aggregates and their associated organic carbon in a field mulched with gravel
Gravel and sand mulching is an indigenous technology that has been used for increasing soil temperature and improving crop yield and water use efficiency for at least 300 years in northwestern China. However, ...
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Article
Open AccessA simple and rapid diagnostic method for 13 types of high-risk human papillomavirus (HR-HPV) detection using CRISPR-Cas12a technology
Cervical carcinoma is the second most common cancer in women worldwide with greater than 99% of the cases caused by human papillomaviruses (HPVs). Early detection of HPVs especially the high risk types (HR-HPV...
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Article
Open AccessCombined quantum tunnelling and dielectrophoretic trap** for molecular analysis at ultra-low analyte concentrations
Quantum tunnelling offers a unique opportunity to study nanoscale objects with atomic resolution using electrical readout. However, practical implementation is impeded by the lack of simple, stable probes, tha...
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Article
Open AccessEvidences for a role of two Y-specific genes in sex determination in Populus deltoides
Almost all plants in the genus Populus are dioecious (i.e. trees are either male or female), but it is unknown whether dioecy evolved in a common ancestor or independently in different subgenera. Here, we sequenc...
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Open AccessOnline quantitative partial discharge monitor based on interferometry
Interferometry-based online partial discharge (PD) monitor presented in this paper can detect the occurrence of PD sensitively, evaluate the peak value of the discharge inception voltage with random waveform a...
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Article
Open AccessControls on surface water carbonate chemistry along North American ocean margins
Syntheses of carbonate chemistry spatial patterns are important for predicting ocean acidification impacts, but are lacking in coastal oceans. Here, we show that along the North American Atlantic and Gulf coas...
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Article
Open AccessAttribution Analysis of Runoff Change in Min-Tuo River Basin based on SWAT model simulations, China
To consummate watershed data and better quantify the impact of climate changes and human activities on runoff, we examined the changes and response mechanisms of runoff in the Min–Tuo River Basin, China. In th...
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Open AccessClimatic modulation of surface acidification rates through summertime wind forcing in the Southern Ocean
While the effects of the Southern Annular Mode (SAM), a dominant climate variability mode in the Southern Ocean, on ocean acidification have been examined using models, no consensus has been reached. Using obs...
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Open AccessHydrological simulation and uncertainty analysis using the improved TOPMODEL in the arid Manas River basin, China
Understanding the mechanism of complicated hydrological processes is important for sustainable management of water resources in an arid area. This paper carried out the simulations of water movement for the Ma...
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Open AccessChange in Land Use and Evapotranspiration in the Manas River Basin, China with Long-term Water-saving Measures
Widespread application of water-saving measures, especially advanced drip irrigation technologies, may significantly impact on the land use, and further potentially alter regional ecological environments in an...
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Open AccessStudy on the characteristics of future precipitation in response to external changes over arid and humid basins
The simulation abilities of the Coupled Model Inter-comparison Project Phase 5 (CMIP5) models to the arid basin (the Tarim River Basin, TRB) and humid basin (the Yangtze River Basin, YRB) were evaluated, deter...