26 Result(s)
within
Lian** Ge
Life Sciences
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Article
A dual role of ERGIC-localized Rabs in TMED10-mediated unconventional protein secretion
Cargo translocation across membranes is a crucial aspect of secretion. In conventional secretion signal peptide-equipped proteins enter the endoplasmic reticulum (ER), whereas a subset of cargo lacking signal ...
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Article
Author Correction: Designing a synthetic moss genome using GenoDesigner
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Article
Designing a synthetic moss genome using GenoDesigner
The de novo synthesis of genomes has made unprecedented progress and achieved milestones, particularly in bacteria and yeast. However, the process of synthesizing a multicellular plant genome has not progresse...
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Article
Next questions in autophagy
Our understanding of the basic mechanisms of autophagy is growing, but many questions remain about the types of autophagy cells use, when they use them, and how they function in different contexts. We asked em...
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TMED10-mediated unconventional secretion of IL-33 regulates intestinal epithelium differentiation and homeostasis
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Article
Stay in touch with the endoplasmic reticulum
The endoplasmic reticulum (ER), which is composed of a continuous network of tubules and sheets, forms the most widely distributed membrane system in eukaryotic cells. As a result, it engages a variety of orga...
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A designer synthetic chromosome fragment functions in moss
Rapid advances in DNA synthesis techniques have enabled the assembly and engineering of viral and microbial genomes, presenting new opportunities for synthetic genomics in multicellular eukaryotic organisms. T...
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Article
Open AccessCharacterization of monoclonal antibodies against porcine epidemic diarrhea virus S1/S2 junction protein
Pig producers have faced considerable economic losses due to porcine epidemic diarrhea virus (PEDV) infection, emphasizing the need for PEDV antibody development. The S1/S2 junction (S1S2J) cleavage site of th...
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Article
Open AccessGeneration of immunodeficient pig with hereditary tyrosinemia type 1 and their preliminary application for humanized liver
Mice with humanized livers are important models to study drug toxicology testing, development of hepatitis virus treatments, and hepatocyte transplantation therapy. However, the huge difference between mouse a...
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miR-361-3p mitigates hypoxia-induced cardiomyocyte injury via targeting apoptosis initiators caspase-2/-8/-9
Acute myocardial infarction (AMI) is an ischemic heart disease with high mortality. AMI-induced hypoxia will trigger serious myocardial injury, such as cardiomyocyte apoptosis. miRNAs have been reported to be ...
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Article
A new type of ERGIC–ERES membrane contact mediated by TMED9 and SEC12 is required for autophagosome biogenesis
Under stress, the endomembrane system undergoes reorganization to support autophagosome biogenesis, which is a central step in autophagy. How the endomembrane system remodels has been poorly understood. Here w...
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Article
Open AccessRapid identification of mutations caused by fast neutron bombardment in Medicago truncatula
Fast neutron bombardment (FNB) is a very effective approach for mutagenesis and has been widely used in generating mutant libraries in many plant species. The main type of mutations of FNB mutants are deletion...
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Article
Open AccessShort-chain fatty acids can improve lipid and glucose metabolism independently of the pig gut microbiota
Previous studies have shown that exogenous short-chain fatty acids (SCFAs) introduction attenuated the body fat deposition in conventional mice and pigs. However, limited studies have evaluated the effects of ...
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Open AccessMulti-omics analysis reveals the glycolipid metabolism response mechanism in the liver of genetically improved farmed Tilapia (GIFT, Oreochromis niloticus) under hypoxia stress
Dissolved oxygen (DO) in the water is a vital abiotic factor in aquatic animal farming. A hypoxic environment affects the growth, metabolism, and immune system of fish. Glycolipid metabolism is a vital energy ...
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Open AccessGenome-wide study of C2H2 zinc finger gene family in Medicago truncatula
C2H2 zinc finger proteins (C2H2 ZFPs) play vital roles in sha** many aspects of plant growth and adaptation to the environment. Plant genomes harbor hundreds of C2H2 ZFPs, which compose one of the most impor...
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Establishment of porcine and human expanded potential stem cells
We recently derived mouse expanded potential stem cells (EPSCs) from individual blastomeres by inhibiting the critical molecular pathways that predispose their differentiation. EPSCs had enriched molecular sig...
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Cell-Free Reconstitution of Autophagic Membrane Formation
Autophagy is a catabolic pathway for bulk turnover of cytoplasmic components through the lysosome. Completion of autophagy requires a sophisticated membrane remodeling process. The early steps involve autophag...
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Article
Synthesis and biological evaluation of novel aliphatic acid-conjugated antimicrobial peptides as potential agents with anti-tumor, multidrug resistance-reversing activity and enhanced stability
Compared with traditional anti-tumor drugs, antimicrobial peptides as novel anti-tumor agents have prominent advantages of higher specificity and circumvention of multi-drug resistance. BP100 is a multifunctio...
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Article
Negative gravitropism in plant roots
Plants are capable of orienting their root growth towards gravity in a process termed gravitropism, which is necessary for roots to grow into soil, for water and nutrient acquisition and to anchor plants. Here...
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Article
Open AccessA de novo silencer causes elimination of MITF-M expression and profound hearing loss in pigs
Genesis of novel gene regulatory modules is largely responsible for morphological and functional evolution. De novo generation of novel cis-regulatory elements (CREs) is much rarer than genomic events that alter ...
