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Article
Isolation and characterization of conserved non-coding sequences among rice (Oryza sativa L.) paralogous regions
Segmental duplication is particularly frequent within plant genomes and the ability of the original single-copy gene to gain a new function for the change of regulatory elements is one of the prominent consequ...
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Article
Differential gene expression and associated QTL map** for cotton yield based on a cDNA-AFLP transcriptome map in an immortalized F2
cDNA-AFLP techniques have found new applications in recent years. Currently, the methodology is used to establish differential gene expression and construct linkage maps. In the present study, a transcriptome ...
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Article
Crystal structures of the extracellular domain of LRP6 and its complex with DKK1
LRP5/6 is a Wnt co-receptor essential for Wnt/β-catenin signaling. X-ray crystallography and electron microscopy analyses now reveal that the LRP6 extracellular ligand-binding domain is composed of two pairs o...
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Article
Controlled Endolysosomal Release of Agents by pH-responsive Polymer Blend Particles
A key step of delivering extracellular agents to its intracellular target is to escape from endosomal/lysosomal compartments, while minimizing the release of digestive enzymes that may compromise cellular func...
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Protocol
Random Spherically Constrained Single-Particle (RSC) Method to Study Voltage-Gated Ion Channels
To study membrane protein structures using cryo-Electron Microscopy (cryo-EM), membrane proteins are usually extracted from cell membranes and solubilized in detergents. To restore the lipid bilayer environmen...
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Article
PpV, acting via the JNK pathway, represses apoptosis during normal development of Drosophila wing
Apoptosis is one of the main fundamental biological processes required for development of multicellular organisms. Inappropriate regulation of apoptosis can lead to severe developmental abnormalities and disea...
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Article
Discovery of a first-in-class CDK2 selective degrader for AML differentiation therapy
The discovery of effective therapeutic treatments for cancer via cell differentiation instead of antiproliferation remains a great challenge. Cyclin-dependent kinase 2 (CDK2) inactivation, which overcomes the ...