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  1. No Access

    Article

    Discovery of a first-in-class CDK2 selective degrader for AML differentiation therapy

    The discovery of effective therapeutic treatments for cancer via cell differentiation instead of antiproliferation remains a great challenge. Cyclin-dependent kinase 2 (CDK2) inactivation, which overcomes the ...

    Liguo Wang, Xue**g Shao, Tianbai Zhong, Yue Wu, Aixiao Xu… in Nature Chemical Biology (2021)

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    Article

    PpV, acting via the JNK pathway, represses apoptosis during normal development of Drosophila wing

    Apoptosis is one of the main fundamental biological processes required for development of multicellular organisms. Inappropriate regulation of apoptosis can lead to severe developmental abnormalities and disea...

    Chunli Chi, Liguo Wang, Wenwen Lan, Long Zhao, Ying Su in Apoptosis (2018)