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    Discovery of a first-in-class CDK2 selective degrader for AML differentiation therapy

    The discovery of effective therapeutic treatments for cancer via cell differentiation instead of antiproliferation remains a great challenge. Cyclin-dependent kinase 2 (CDK2) inactivation, which overcomes the ...

    Liguo Wang, Xue**g Shao, Tianbai Zhong, Yue Wu, Aixiao Xu… in Nature Chemical Biology (2021)