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Article
Open AccessCryo2StructData: A Large Labeled Cryo-EM Density Map Dataset for AI-based Modeling of Protein Structures
The advent of single-particle cryo-electron microscopy (cryo-EM) has brought forth a new era of structural biology, enabling the routine determination of large biological molecules and their complexes at atomi...
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Article
Promiscuous G-protein activation by the calcium-sensing receptor
The human calcium-sensing receptor (CaSR) detects fluctuations in the extracellular Ca2+ concentration and maintains Ca2+ homeostasis1,2. It also mediates diverse cellular processes not associated with Ca2+ balan...
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Article
Open AccessCorrelative single-cell hard X-ray computed tomography and X-ray fluorescence imaging
X-ray computed tomography (XCT) and X-ray fluorescence (XRF) imaging are two non-invasive imaging techniques to study cellular structures and chemical element distributions, respectively. However, correlative ...
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Article
Open AccessA novel iterative detection method based on a lattice reduction-aided algorithm for MIMO OFDM systems
The lattice reduction-aided algorithm has received broad attention from researchers since it operates as a maximum likelihood receiver with better system performance for multiple-input multiple-output orthogon...
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Article
Microstructure and Mechanical Properties of Friction Stir Welded LAZ931 Duplex Mg-Li Alloy Plates
Friction stir welding was successfully applied to duplex Mg-8.9Li-3.5Al-0.9Zn (LAZ931) alloy plates with a thickness of 5.2 mm utilizing a steel tool at a constant tool rotation speed of 800 rpm and different ...
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Article
Discovery of small molecule degraders for modulating cell cycle
The cell cycle is a complex process that involves DNA replication, protein expression, and cell division. Dysregulation of the cell cycle is associated with various diseases. Cyclin-dependent kinases (CDKs) an...
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Article
Open AccessGain-of-function mutant p53 together with ERG proto-oncogene drive prostate cancer by beta-catenin activation and pyrimidine synthesis
Whether TMPRSS2-ERG fusion and TP53 gene alteration coordinately promote prostate cancer (PCa) remains unclear. Here we demonstrate that TMPRSS2-ERG fusion and TP53 mutation / deletion co-occur in PCa patient spe...
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Article
Publisher Correction: Reference-guided search for open reading frames
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Article
Reference-guided search for open reading frames
A recent study proposes an approach for identifying open reading frames that uses reference annotation to improve the accuracy of the detection.
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Article
A cost-effective approach to manufacturing ultra-high-performance lightweight concrete via air-entraining
Ultra-high-performance concrete (UHPC) has attracted wide interests in civil engineering but it has large deadweight, which limits its application in lightweight structures and rehabilitation. Compromising the...
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Article
Enhanced Corrosion Resistance and Mechanical Properties of Mg-Zn Alloy via Micro-alloying of Ge
Generally, the corrosion of magnesium (Mg) and its alloys is accompanied by hydrogen production, which can cause gas pockets and severe biological problems when they are used as implants. Germanium (Ge) as an ...
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Article
Open AccessA large expert-curated cryo-EM image dataset for machine learning protein particle picking
Cryo-electron microscopy (cryo-EM) is a powerful technique for determining the structures of biological macromolecular complexes. Picking single-protein particles from cryo-EM micrographs is a crucial step in ...
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Article
Open AccessExtensive intratumor regional epigenetic heterogeneity in clear cell renal cell carcinoma targets kidney enhancers and is associated with poor outcome
Clear cell renal cell cancer (ccRCC), the 8th leading cause of cancer-related death in the US, is challenging to treat due to high level intratumoral heterogeneity (ITH) and the paucity of druggable driver mut...
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Chapter and Conference Paper
Study on Flow of Helium II Through a Porous Element for a Fountain Effect Pump
Numerical study on the thermodynamic flow of superfluid helium (Helium II) through a porous element for a fountain effect pump is carried out. The mathematical model of turbulent flow in unsteady state was est...
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Article
Prediction of electronic work function of the second phase in binary magnesium alloy based on machine learning method
In this paper, 150 pieces of the work function of Mg-based solid solutions and Mg-containing second phases calculated by our group based on density functional theory (DFT) were collected to build a data set. A...
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Article
Open AccessImprovement of drilling quality using precision directional drilling technology
The problem of boreholes deflection in coal mines is common, especially in soft and hard composite coal seams. As a result, the distribution of boreholes is uneven and forms a blank zone in the drainage area, ...
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Article
On-line identifying stator winding short-circuit approach for a submersible motor based on faulty current monitoring
To monitor, diagnose, and suppress the inter-turn short-circuit faults (ITSCFs) of a submersible motor, an approach for the on-line identification of its winding faults has been proposed based on monitoring th...
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Article
Open AccessRetinoblastoma protein as an intrinsic BRD4 inhibitor modulates small molecule BET inhibitor sensitivity in cancer
Bromodomain and extraterminal (BET) proteins including BRD4 play important roles in oncogenesis and immune inflammation. Here we demonstrate that cancer cells with loss of the retinoblastoma (RB) tumor suppres...
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Article
A highly energy-efficient and ductile building material reinforced by micro-PCMs
Micro-encapsulated phase change materials (micro-PCMs) were utilized to equip fiber-reinforced concrete (FRC) with stronger ductility and better energy storage capacity. Experimental results indicated that 6.0...
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Article
Permeability improvement mechanism and application of large-diameter mechanical caving drilling technology for promoting coal gas drainage
A proper understanding of large-diameter mechanical caving drilling technology is essential, because this technology can effectively improve the efficiency of gas extraction. Therefore, this paper firstly intr...
