63 Result(s)
within
LiGuang Sun
English
-
Article
Open AccessA 1500-year record of mercury isotopes in seal feces documents sea ice changes in the Antarctic
Temporal and spatial variations in sea ice coverage at high Northern Hemisphere latitudes have been shown to affect the photodegradation of methylmercury in seawater and the mercury isotope signatures in biolo...
-
Article
Open AccessSirt6-mediated epigenetic modification of DNA accessibility is essential for Pou2f3-induced thymic tuft cell development
Thymic epithelial cells (TECs) are essential for the production of self-tolerant T cells. The newly identified thymic tuft cells are regulated by Pou2f3 and represent important elements for host type 2 immunity. ...
-
Article
Open AccessCurrent status of clinical trials assessing mesenchymal stem cell therapy for graft versus host disease: a systematic review
Graft-versus-host disease (GVHD) is a common fatal complication of hematopoietic stem cell transplantation (HSCT), where steroids are used as a treatment option. However, there are currently no second-line tre...
-
Article
Palaeo-notch sediments as reliable proxy records for climate change and anthropogenic activities: a short review
Over the past decades, many proxy materials (for example, lacustrine sediments, marine sediments, ice cores, loess, and tree rings) have been used to reconstruct palaeoclimatic and palaeoenvironmental changes....
-
Article
Possible reasons for an extreme ecological disaster event in Zhoushan Archipelago during the period 5900–5600 yr BP
A 3.3-m-thick, 74.5-m-long ancient wood layer was discovered in Zhoushan Archipelago, East China Sea. The ancient woods were well preserved except for weak silicification of wood bark, and abundant amount of l...
-
Article
Open AccessHolocene ENSO variability in the South China Sea recorded by high-resolution oxygen isotope records from the shells of Tridacna spp.
The El Niño-Southern Oscillation (ENSO) is the principal climatic system in the modern Pacific Ocean, and it potentially influences the global climate. The South China Sea (SCS), in the western tropical Pacifi...
-
Article
Evidence for glacial deposits during the Little Ice Age in Ny-Alesund, western Spitsbergen
The glaciers act as an important proxy of climate changes; however, little is known about the glacial activities in Ny-Alesund during the Little Ice Age (LIA). In the present study, we studied a 118-cm-high pa...
-
Article
Open AccessNK cell predicts the severity of acute graft-versus-host disease in patients after allogeneic stem cell transplantation using antithymocyte globulin (ATG) in pretreatment scheme
Graft-versus-host disease (GVHD) is one of the most complex complications after allogeneic stem cell transplantation. Current standard of grading system is based on clinical symptoms in skin, liver and intesti...
-
Article
Open AccessLow dose of IL-2 combined with rapamycin restores and maintains the long-term balance of Th17/Treg cells in refractory SLE patients
The development of Systemic lupus erythematosus (SLE) has been associated with the balance of Th17 and Treg cells. IL-2 and rapamycin can influence the populations of both Th17 and Treg cells. However, it is u...
-
Article
Total photosynthetic biomass record between 9400 and 2200 BP and its link to temperature changes at a High Arctic site near Ny-Ålesund, Svalbard
Changes in vegetation biomass have a great impact on many aspects of the Arctic ecosystem, and historical variations of biomass in Svalbard during the Holocene remain poorly understood. In this study, we colle...
-
Article
Lead Neurotoxicity on Human Neuroblastoma Cell Line SH-SY5Y is Mediated via Transcription Factor EGR1/Zif268 Induced Disrupted in Scherophernia-1 Activation
Lead (Pb2+) is a well-known type of neurotoxin and chronic exposure to Pb2+ induces cognition dysfunction. In this work, the potential role of early growth response gene 1 (EGR1) in the linkage of Pb2+ exposure a...
-
Article
Mid-to-late Holocene climate change record in palaeo-notch sediment from London Island, Svalbard
The Arctic region is very sensitive to climate change and important in the Earth’s climate system. However, proxy datasets for Arctic climate are unevenly distributed and especially scarce for Svalbard because...
-
Article
Open AccessAssociation of serum sodium and risk of all-cause mortality in patients with chronic kidney disease: A meta-analysis and sysematic review
Studies on the association of dysnatraemia with all-cause mortality risk in chronic kidney disease (CKD) patients have yielded inconsistent results. This meta-analysis aimed to evaluate the association of hypo...
-
Article
Open AccessThe Potential of Alkyl Amides as Novel Biomarkers and Their Application to Paleocultural Deposits in China
A series of alkyl amides was detected and identified in the sedimentary record from an archaeological site at Yuchisi, Mengcheng, Anhui, China. The alkyl amides profiles change abruptly at the depth correspond...
-
Article
Antithymocyte globulin treatment at the time of transplantation impairs donor hematopoietic stem cell engraftment
Antithymocyte globulin (ATG) is often included in the conditioning regimen to prevent graft vs. host disease in allogeneic hematopoietic stem cell (HSC) transplantation. However, because ATG contains antibodie...
-
Article
Open AccessMicrobial community composition is related to soil biological and chemical properties and bacterial wilt outbreak
Soil microbes play important roles in plant growth and health. Little is known about the differences of soil microbes between healthy and bacterial wilt infected soils with Ralstonia solanacearum. By Illumina-MiS...
-
Article
A great volcanic eruption around AD 1300 recorded in lacustrine sediment from Dongdao Island, South China Sea
The contents of Ti, Al and Fe 2 O 3 in a lacustrine sediment core (DY6) collected from Dongdao Island, South China Sea (SCS), were determined to be much higher than...
-
Article
Open AccessDecline of recent seabirds inferred from a composite 1000-year record of population dynamics
Based on three ornithogenic sediment profiles and seabird subfossils therein from the **sha Islands, South China Sea, the relative population size of seabirds over the past 1000 years was reconstructed using r...
-
Article
Open AccessAberrant DNA methylation reprogramming in bovine SCNT preimplantation embryos
DNA methylation reprogramming plays important roles in mammalian embryogenesis. Mammalian somatic cell nuclear transfer (SCNT) embryos with reprogramming defects fail to develop. Thus, we compared DNA methylat...
-
Article
Open AccessThe abrupt climate change near 4,400 yr BP on the cultural transition in Yuchisi, China and its global linkage
Extreme climatic events have profound impacts on human society. Here we present the results of a study of organic biomarkers within a sedimentary section at the archaeological site of Yuchisi, eastern China, i...
