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  1. Article

    Open Access

    Focal Adhesion Kinase Regulates Hepatic Stellate Cell Activation and Liver Fibrosis

    Understanding the underlying molecular mechanisms of liver fibrosis is important to develop effective therapy. Herein, we show that focal-adhesion-kinse (FAK) plays a key role in promoting hepatic stellate cel...

    Xue-Ke Zhao, Lei Yu, Ming-Liang Cheng, Pulin Che, Yin-Ying Lu in Scientific Reports (2017)

  2. Article

    Open Access

    Saccharomyces boulardii Administration Changes Gut Microbiota and Attenuates D-Galactosamine-Induced Liver Injury

    Growing evidence has shown that gut microbiome is a key factor involved in liver health. Therefore, gut microbiota modulation with probiotic bacteria, such as Saccharomyces boulardii, constitutes a promising ther...

    Lei Yu, Xue-ke Zhao, Ming-liang Cheng, Guo-zhen Yang, Bi Wang in Scientific Reports (2017)

  3. Article

    Open Access

    Quantitative assessment of common genetic variations in HLA-DP with hepatitis B virus infection, clearance and hepatocellular carcinoma development

    Hepatitis B virus (HBV) infection is the predominant risk factor for chronic hepatitis B (CHB), liver cirrhosis (LC) and hepatocellular carcinoma (HCC). Recently, genome-wide association studies have identifie...

    Lei Yu, Yi-ju Cheng, Ming-liang Cheng, Yu-mei Yao, Quan Zhang in Scientific Reports (2015)

  4. Article

    Open Access

    Effect of supersaturation on hillock of directional Growth of KDP crystals

    KDP single crystals were grown in aqueous solution by using “point seeds” with a defined crystallographic direction of 59° to the Z axis. When hillock slopes on the (100) face of KDP crystals were measured wit...

    Fa-Fu Liu, Guang-Wei Yu, Li-Song Zhang, Liang Li, Bo Wang in Scientific Reports (2014)