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Article
Open AccessBrainstem Dbh+ neurons control allergen-induced airway hyperreactivity
Exaggerated airway constriction triggered by repeated exposure to allergen, also called hyperreactivity, is a hallmark of asthma. Whereas vagal sensory neurons are known to function in allergen-induced hyperre...
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Article
Open AccessThe association between internet use and the choice of medical institution among Chinese older adults
As older people have complex medical needs and still encounter challenges in accessing online health information, the relationship between Internet use and the choice of medical institution made by them is unc...
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Article
Open AccessThe effects of meteorological factors and air pollutants on the incidence of tuberculosis in people living with HIV/AIDS in subtropical Guangxi, China
Previous studies have shown the association between tuberculosis (TB) and meteorological factors/air pollutants. However, little information is available for people living with HIV/AIDS (PLWHA), who are highly...
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Article
Open AccessFull life cycle changes of low impacted mandibular third molar associated cystic lesions and adjacent tooth root resorption: a retrospective study
Low impacted third molars are usually asymptomatic and are often found by X-ray examination. The removal of asymptomatic low impacted third molars is one of the most controversial clinical issues in oral and m...
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Article
Open AccessThe Application of Aptamer and Research Progress in Liver Disease
Aptamers, as a kind of small-molecule nucleic acid, have attracted much attention since their discovery. Compared with biological reagents such as antibodies, aptamers have the advantages of small molecular we...
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Article
Open AccessCritically ill children with SARS-COV-2 Omicron infection at a national children medical center, Guangdong, China
SARS-CoV-2 infection is described as asymptomatic, mild, or moderate disease in most children. SARS-CoV-2 infection related death in children and adolescents is rare according to the current reports. COVID-19 ...
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Article
Open AccessMiR-449b-5p Ameliorates Hypoxia-induced Cardiomyocyte Injury through Activating PI3K/AKT Pathway by Targeting BCL2L13
Recent reports show miR-449b-5p reduces liver and renal ischemia/reperfusion (I/R) injury, but its effects on hypoxia-induced cardiomyocyte injury in ischemic heart disease are still unknown. In this study, AC...
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Article
Open AccessComparison of laser guidance and freehand hook-wire for CT-guided preoperative localization of pulmonary nodules
In VATS surgery, precise preoperative localization is particularly crucial when dealing with small-diameter pulmonary nodules located deep within the lung parenchyma. The purpose of this study was to compare t...
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Article
Open AccessIdentification of immune-associated biomarker for predicting lung adenocarcinoma: bioinformatics analysis and experiment verification of PTK6
Abnormal expression of protein tyrosine kinase 6 (PTK6) has been proven to be involved in the development of gynecological tumors. However, its immune-related carcinogenic mechanism in other tumors remains unc...
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Article
Open AccessIdentification of the shared hub gene signatures and molecular mechanisms between HIV-1 and pulmonary arterial hypertension
The close link between HIV-1 infection and the occurrence of pulmonary arterial hypertension (PAH). However, the underlying molecular mechanisms of their interrelation remain unclear. The microarray data of HI...
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Article
Open AccessEffectiveness of human immunodeficiency virus prevention strategies by map** the geographic dispersion pattern of human immunodeficiency virus prevalence in Nanning, China
The Guangxi government initiated two rounds of the Guangxi AIDS Conquering Project (GACP) in 2010 (Phase I) and 2015 (Phase II) to control human immunodeficiency virus (HIV)/acquired immunodeficiency syndrome ...
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Article
Open AccessEvidence linking COVID-19 and the health/well-being of children and adolescents: an umbrella review
Experiences during childhood and adolescence have enduring impacts on physical and mental well-being, overall quality of life, and socioeconomic status throughout one’s lifetime. This underscores the importanc...
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Article
Open AccessThe origin, dissemination, and molecular networks of HIV-1 CRF65_cpx strain in Hainan Island, China
HIV-1 CRF65_cpx strain carries drug-resistant mutations, which raises concerns about its potential for causing virologic failure. The CRF65_cpx ranks as the fourth most prevalent on Hainan Island, China. Howev...
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Article
Open AccessA bibliometric analysis of m6A methylation in viral infection from 2000 to 2022
N6-methyladenosine (m6A) methylation has become an active research area in viral infection, while little bibliometric analysis has been performed. In this study, we aim to visualize hotspots and trends using b...
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Article
Open AccessCausal relationship between gut microbiota and tuberculosis: a bidirectional two-sample Mendelian randomization analysis
Growing evidence from observational studies and clinical trials suggests that the gut microbiota is associated with tuberculosis (TB). However, it is unclear whether any causal relationship exists between them...
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Article
Open AccessAutophagy of OTUD5 destabilizes GPX4 to confer ferroptosis-dependent kidney injury
Ferroptosis is an iron-dependent programmed cell death associated with severe kidney diseases, linked to decreased glutathione peroxidase 4 (GPX4). However, the spatial distribution of renal GPX4-mediated ferr...
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Article
Open AccessHuman microbiota dysbiosis after SARS-CoV-2 infection have the potential to predict disease prognosis
The studies on SARS-CoV-2 and human microbiota have yielded inconsistent results regarding microbiota α-diversity and key microbiota. To address these issues and explore the predictive ability of human microbi...
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Article
Open AccessVagal sensory neurons mediate the Bezold–Jarisch reflex and induce syncope
Visceral sensory pathways mediate homeostatic reflexes, the dysfunction of which leads to many neurological disorders1. The Bezold–Jarisch reflex (BJR), first described2,3 in 1867, is a cardioinhibitory reflex th...
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Article
Open AccessRisk factors analysis of surgical site infections in postoperative colorectal cancer: a nine-year retrospective study
Colorectal cancer (CRC) patients undergoing surgery are at a high risk of develo** surgical site infections (SSIs), which contribute to increased morbidity, prolonged hospitalization, and escalated healthcar...
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Article
Open AccessTalaromyces marneffei suppresses macrophage inflammation by regulating host alternative splicing
Talaromyces marneffei (T. marneffei) immune escape is essential in the pathogenesis of talaromycosis. It is currently known that T. marneffei achieves immune escape through various strategies. However, the role o...
