28 Result(s)

Article

Brainstem Dbh⁺ neurons control allergen-induced airway hyperreactivity

Exaggerated airway constriction triggered by repeated exposure to allergen, also called hyperreactivity, is a hallmark of asthma. Whereas vagal sensory neurons are known to function in allergen-induced hyperre...

Yujuan Su, **hao Xu, Ziai Zhu, Jisun Chin, Le Xu, Haoze Yu, Victoria Nudell… in Nature (2024)

Article

Identification of the shared hub gene signatures and molecular mechanisms between HIV-1 and pulmonary arterial hypertension

The close link between HIV-1 infection and the occurrence of pulmonary arterial hypertension (PAH). However, the underlying molecular mechanisms of their interrelation remain unclear. The microarray data of HI...

Huanzhuo Mai, **ng Yang, Yulan **e, Jie Zhou, Yiru Wei, Tingyan Luo… in Scientific Reports (2024)

Article

Autophagy of OTUD5 destabilizes GPX4 to confer ferroptosis-dependent kidney injury

Ferroptosis is an iron-dependent programmed cell death associated with severe kidney diseases, linked to decreased glutathione peroxidase 4 (GPX4). However, the spatial distribution of renal GPX4-mediated ferr...

Li-Kai Chu, Xu Cao, Lin Wan, Qiang Diao, Yu Zhu, Yu Kan, Li-Li Ye… in Nature Communications (2023)

Article

Vagal sensory neurons mediate the Bezold–Jarisch reflex and induce syncope

Visceral sensory pathways mediate homeostatic reflexes, the dysfunction of which leads to many neurological disorders¹. The Bezold–Jarisch reflex (BJR), first described^2,3 in 1867, is a cardioinhibitory reflex th...

Jonathan W. Lovelace, **grui Ma, Saurabh Yadav, Karishma Chhabria, Hanbing Shen… in Nature (2023)

Article

Retraction Note: Mir20a/106a-WTX axis regulates RhoGDIa/CDC42 signaling and colon cancer progression

Gui-fang Zhu, Yang-wei Xu, Jian Li, Hui-lin Niu, Wen-xia Ma… in Nature Communications (2023)

Article

**phoid nucleus of the midline thalamus controls cold-induced food seeking

Maintaining body temperature is calorically expensive for endothermic animals¹. Mammals eat more in the cold to compensate for energy expenditure², but the neural mechanism underlying this coupling is not well un...

Neeraj K. Lal, Phuong Le, Samarth Aggarwal, Alan Zhang, Kristina Wang, Tianbo Qi… in Nature (2023)

Article

The role of somatosensory innervation of adipose tissues

Adipose tissues communicate with the central nervous system to maintain whole-body energy homeostasis. The mainstream view is that circulating hormones secreted by the fat convey the metabolic state to the bra...

Yu Wang, Verina H. Leung, Yunxiao Zhang, Victoria S. Nudell, Meaghan Loud… in Nature (2022)

Article

90-90-90 cascade analysis on reported CLHIV infected by mother-to-child transmission in Guangxi, China: a modeling study

The prevalence of HIV in Guangxi was very high, and there were many children living with HIV (CLHIV) because of larger baseline of pregnant women infected by HIV. It is necessary for children to explore the st...

Gang Wang, Chunyan Lu, Shanfang Qin, Wudi Wei, **gzhen Lai… in Scientific Reports (2020)

Article

Multimodal image registration and connectivity analysis for integration of connectomic data from microscopy to MRI

3D histology, slice-based connectivity atlases, and diffusion MRI are common techniques to map brain wiring. While there are many modality-specific tools to process these data, there is a lack of integration a...

Maged Goubran, Christoph Leuze, Brian Hsueh, Markus Aswendt, Li Ye… in Nature Communications (2019)

Article

An optimal BMI range associated with a lower risk of mortality among HIV-infected adults initiating antiretroviral therapy in Guangxi, China

Previous studies investigating HIV-infected patients suggested a direct link between underweight and the mortality rate of AIDS. However, there was a lack of evidence showing the optimal range of initial body ...

Junjun Jiang, **onglin Qin, Huifang Liu, Sirun Meng, Abu S. Abdullah… in Scientific Reports (2019)

Article

RETRACTED ARTICLE: Mir20a/106a-WTX axis regulates RhoGDIa/CDC42 signaling and colon cancer progression

Wilms tumor gene on the X chromosome (WTX) is a putative tumor suppressor gene in Wilms tumor, but its expression and functions in other tumors are unclear. Colorectal cancer (CRC) is the third leading cause of c...

Gui-fang Zhu, Yang-wei Xu, Jian Li, Hui-lin Niu, Wen-xia Ma… in Nature Communications (2019)

Article

Impact of worker emigration on HIV epidemics in labour export areas: a molecular epidemiology investigation in Guangyuan, China

We aimed to investigate the molecular epidemic characteristics and viral transmission patterns of HIV-1 in a typical labor export area, Guangyuan city, China. Based on conducting phylogenetic trees and molecul...

Ling Su, Shu Liang, Xueqin Hou, ** Zhong, Dongbing Wei, Yu Fu… in Scientific Reports (2018)

Article

Publisher Correction: PP2A inhibition from LB100 therapy enhances daunorubicin cytotoxicity in secondary acute myeloid leukemia via miR-181b-1 upregulation

A correction to this article has been published and is linked from the HTML version of this paper. The error has been fixed in the paper.

Chao Hu, Mengxia Yu, Yanling Ren, Kongfei Li, Dominic M. Maggio… in Scientific Reports (2017)

Article

Impact of Educational Interventions on Acceptance and Uptake of Male Circumcision in the General Population of Western China: A Multicenter Cohort Study

To compare different intervention models for promoting male circumcision (MC) to prevent HIV transmission in Western China. A total of 1690 male participants from multiple study sites were cluster randomly all...

Bo Zhou, Chuanyi Ning, Chase D. McCann, Yanyan Liao, **aobo Yang… in Scientific Reports (2017)

Article

Opiate use inhibits TLR9 signaling pathway in vivo: possible role in pathogenesis of HIV-1 infection

The molecular mechanism of opiate use promoting HIV-1 infection is not fully understood. TLR9 is expressed in many immune cells, including monocytes, macrophages, which can recognize viruses and viral products...

Yanyan Liao, Junjun Jiang, Bingyu Liang, Fumei Wei, Jiegang Huang… in Scientific Reports (2017)

Article

Pathways to clinical CLARITY: volumetric analysis of irregular, soft, and heterogeneous tissues in development and disease

Three-dimensional tissue-structural relationships are not well captured by typical thin-section histology, posing challenges for the study of tissue physiology and pathology. Moreover, while recent progress ha...

Brian Hsueh, Vanessa M. Burns, Philip Pauerstein, Katherine Holzem… in Scientific Reports (2017)

Article

Prospective evaluation of the diagnostic value of plasma apelin 12 levels for differentiating patients with moyamoya and intracranial atherosclerotic diseases

Patients with moyamoya disease (MMD) or intracranial atherosclerotic disease (ICAD) experience similar cerebral ischaemic events. However, MMD patients show greater angiogenesis and arteriogenesis, which play ...

Wei Hu, Wan Jiang, Li Ye, Yanghua Tian, Bing Shen, Kai Wang in Scientific Reports (2017)

Article

Blocking autophagy improves the anti-tumor activity of afatinib in lung adenocarcinoma with activating EGFR mutations in vitro and in vivo

Afatinib, a second-generation tyrosine kinase inhibitor (TKI), has been approved for the treatment of advanced EGFR-mutant non-small cell lung cancer (NSCLC). However, afatinib’s clinical application is still ham...

**angxiang Hu, Si Shi, Huan Wang, **aochen Yu, Qian Wang… in Scientific Reports (2017)

Article

PP2A inhibition from LB100 therapy enhances daunorubicin cytotoxicity in secondary acute myeloid leukemia via miR-181b-1 upregulation

Patients with secondary acute myeloid leukemia (sAML) arising from myelodysplastic syndromes have a poor prognosis marked by an increased resistance to chemotherapy. An urgent need exists for adjuvant treatmen...

Chao Hu, Mengxia Yu, Yanling Ren, Kongfei Li, Dominic M. Maggio… in Scientific Reports (2017)