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Open AccessBrainstem Dbh+ neurons control allergen-induced airway hyperreactivity
Exaggerated airway constriction triggered by repeated exposure to allergen, also called hyperreactivity, is a hallmark of asthma. Whereas vagal sensory neurons are known to function in allergen-induced hyperre...
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Article
Open AccessIdentification of the shared hub gene signatures and molecular mechanisms between HIV-1 and pulmonary arterial hypertension
The close link between HIV-1 infection and the occurrence of pulmonary arterial hypertension (PAH). However, the underlying molecular mechanisms of their interrelation remain unclear. The microarray data of HI...
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Article
Open AccessAutophagy of OTUD5 destabilizes GPX4 to confer ferroptosis-dependent kidney injury
Ferroptosis is an iron-dependent programmed cell death associated with severe kidney diseases, linked to decreased glutathione peroxidase 4 (GPX4). However, the spatial distribution of renal GPX4-mediated ferr...
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Open AccessVagal sensory neurons mediate the Bezold–Jarisch reflex and induce syncope
Visceral sensory pathways mediate homeostatic reflexes, the dysfunction of which leads to many neurological disorders1. The Bezold–Jarisch reflex (BJR), first described2,3 in 1867, is a cardioinhibitory reflex th...
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Open AccessRetraction Note: Mir20a/106a-WTX axis regulates RhoGDIa/CDC42 signaling and colon cancer progression
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Open Access**phoid nucleus of the midline thalamus controls cold-induced food seeking
Maintaining body temperature is calorically expensive for endothermic animals1. Mammals eat more in the cold to compensate for energy expenditure2, but the neural mechanism underlying this coupling is not well un...
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Open AccessThe role of somatosensory innervation of adipose tissues
Adipose tissues communicate with the central nervous system to maintain whole-body energy homeostasis. The mainstream view is that circulating hormones secreted by the fat convey the metabolic state to the bra...
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Open Access90-90-90 cascade analysis on reported CLHIV infected by mother-to-child transmission in Guangxi, China: a modeling study
The prevalence of HIV in Guangxi was very high, and there were many children living with HIV (CLHIV) because of larger baseline of pregnant women infected by HIV. It is necessary for children to explore the st...
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Open AccessMultimodal image registration and connectivity analysis for integration of connectomic data from microscopy to MRI
3D histology, slice-based connectivity atlases, and diffusion MRI are common techniques to map brain wiring. While there are many modality-specific tools to process these data, there is a lack of integration a...
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Open AccessAn optimal BMI range associated with a lower risk of mortality among HIV-infected adults initiating antiretroviral therapy in Guangxi, China
Previous studies investigating HIV-infected patients suggested a direct link between underweight and the mortality rate of AIDS. However, there was a lack of evidence showing the optimal range of initial body ...
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Open AccessRETRACTED ARTICLE: Mir20a/106a-WTX axis regulates RhoGDIa/CDC42 signaling and colon cancer progression
Wilms tumor gene on the X chromosome (WTX) is a putative tumor suppressor gene in Wilms tumor, but its expression and functions in other tumors are unclear. Colorectal cancer (CRC) is the third leading cause of c...
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Article
Interacting neural ensembles in orbitofrontal cortex for social and feeding behaviour
Categorically distinct basic drives (for example, for social versus feeding behaviour1–3) can exert potent influences on each other; such interactions are likely to have important adaptive consequences (such as a...
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Open AccessImpact of worker emigration on HIV epidemics in labour export areas: a molecular epidemiology investigation in Guangyuan, China
We aimed to investigate the molecular epidemic characteristics and viral transmission patterns of HIV-1 in a typical labor export area, Guangyuan city, China. Based on conducting phylogenetic trees and molecul...
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Open AccessPublisher Correction: PP2A inhibition from LB100 therapy enhances daunorubicin cytotoxicity in secondary acute myeloid leukemia via miR-181b-1 upregulation
A correction to this article has been published and is linked from the HTML version of this paper. The error has been fixed in the paper.
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Open AccessImpact of Educational Interventions on Acceptance and Uptake of Male Circumcision in the General Population of Western China: A Multicenter Cohort Study
To compare different intervention models for promoting male circumcision (MC) to prevent HIV transmission in Western China. A total of 1690 male participants from multiple study sites were cluster randomly all...
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Open AccessOpiate use inhibits TLR9 signaling pathway in vivo: possible role in pathogenesis of HIV-1 infection
The molecular mechanism of opiate use promoting HIV-1 infection is not fully understood. TLR9 is expressed in many immune cells, including monocytes, macrophages, which can recognize viruses and viral products...
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Open AccessPathways to clinical CLARITY: volumetric analysis of irregular, soft, and heterogeneous tissues in development and disease
Three-dimensional tissue-structural relationships are not well captured by typical thin-section histology, posing challenges for the study of tissue physiology and pathology. Moreover, while recent progress ha...
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Open AccessProspective evaluation of the diagnostic value of plasma apelin 12 levels for differentiating patients with moyamoya and intracranial atherosclerotic diseases
Patients with moyamoya disease (MMD) or intracranial atherosclerotic disease (ICAD) experience similar cerebral ischaemic events. However, MMD patients show greater angiogenesis and arteriogenesis, which play ...
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Open AccessBlocking autophagy improves the anti-tumor activity of afatinib in lung adenocarcinoma with activating EGFR mutations in vitro and in vivo
Afatinib, a second-generation tyrosine kinase inhibitor (TKI), has been approved for the treatment of advanced EGFR-mutant non-small cell lung cancer (NSCLC). However, afatinib’s clinical application is still ham...
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Open AccessPP2A inhibition from LB100 therapy enhances daunorubicin cytotoxicity in secondary acute myeloid leukemia via miR-181b-1 upregulation
Patients with secondary acute myeloid leukemia (sAML) arising from myelodysplastic syndromes have a poor prognosis marked by an increased resistance to chemotherapy. An urgent need exists for adjuvant treatmen...