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Article
Open AccessSurplus fatty acid synthesis increases oxidative stress in adipocytes and induces lipodystrophy
Adipocytes are the primary sites for fatty acid storage, but the synthesis rate of fatty acids is very low. The physiological significance of this phenomenon remains unclear. Here, we show that surplus fatty a...
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Article
Open AccessTemperature-dependent interphase formation and Li+ transport in lithium metal batteries
High-performance Li-ion/metal batteries working at a low temperature (i.e., <−20 °C) are desired but hindered by the sluggish kinetics associated with Li+ transport and charge transfer. Herein, the temperature-de...
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Article
Open AccessEnhancing human resilience beyond COVID-19-related stress: public responses to multi-benefits of home gardening
The SARS-CoV-2 virus has caused a public health crisis globally. Against the backdrop of global resilience, studies have demonstrated the therapeutic value of home gardening as a measure to strengthen human he...
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Article
Open AccessAssociation of different obesity patterns with hypertension in US male adults: a cross-sectional study
Obesity is an important risk factor for hypertension. We aimed to investigate the association between different obesity patterns and hypertension risk in a large male population in the US. Male participants fr...
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Article
Open AccessMultifunctional solvent molecule design enables high-voltage Li-ion batteries
Elevating the charging cut-off voltage is one of the efficient approaches to boost the energy density of Li-ion batteries (LIBs). However, this method is limited by the occurrence of severe parasitic reactions...
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Article
Open AccessTailoring polymer electrolyte ionic conductivity for production of low- temperature operating quasi-all-solid-state lithium metal batteries
The stable operation of lithium-based batteries at low temperatures is critical for applications in cold climates. However, low-temperature operations are plagued by insufficient dynamics in the bulk of the el...
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Article
Open AccessAnalysis of clinically relevant variants from ancestrally diverse Asian genomes
Asian populations are under-represented in human genomics research. Here, we characterize clinically significant genetic variation in 9051 genomes representing East Asian, South Asian, and severely under-repre...
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Article
Open AccessTackling realistic Li+ flux for high-energy lithium metal batteries
Electrolyte engineering advances Li metal batteries (LMBs) with high Coulombic efficiency (CE) by constructing LiF-rich solid electrolyte interphase (SEI). However, the low conductivity of LiF disturbs Li+ diffus...
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Article
Open AccessNo association between alcohol consumption and pancreatic cancer even among individuals genetically susceptible to the carcinogenicity of alcohol
Inconsistent results have been reported for the association between alcohol use and pancreatic cancer, particularly at low levels of alcohol consumption. Individuals genetically susceptible to the carcinogenic...
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Article
Open AccessChia, a large annotated corpus of clinical trial eligibility criteria
We present Chia, a novel, large annotated corpus of patient eligibility criteria extracted from 1,000 interventional, Phase IV clinical trials registered in ClinicalTrials.gov. This dataset includes 12,409 ann...
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Article
Open AccessTraditional versus blended CPR training program: A randomized controlled non-inferiority study
Cardiopulmonary resuscitation (CPR) training and its quality are critical in improving the survival rate of cardiac arrest. This randomized controlled study investigated the efficacy of a newly developed CPR t...
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Article
Open AccessAuthor Correction: FTY720 Induces Autophagy-Associated Apoptosis in Human Oral Squamous Carcinoma Cells, in Part, through a Reactive Oxygen Species/Mcl-1-Dependent Mechanism
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
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Article
Open AccessChiral fermion reversal in chiral crystals
In materials chiral fermions such as Weyl fermions are characterized by nonzero chiral charges, which are singular points of Berry curvature in momentum space. Recently, new types of chiral fermions beyond Wey...
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Article
Open AccessPersistence and continuous evolution of the human respiratory syncytial virus in northern Taiwan for two decades
The study aimed to characterize the molecular epidemiology, phylogenetic relationship, and population dynamics of the G protein gene in clinical respiratory syncytial virus (RSV) strains isolated from northern...
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Article
Open AccessCross-ethnic meta-analysis identifies association of the GPX3-TNIP1 locus with amyotrophic lateral sclerosis
Cross-ethnic genetic studies can leverage power from differences in disease epidemiology and population-specific genetic architecture. In particular, the differences in linkage disequilibrium and allele freque...
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Article
Open AccessFTY720 Induces Autophagy-Associated Apoptosis in Human Oral Squamous Carcinoma Cells, in Part, through a Reactive Oxygen Species/Mcl-1-Dependent Mechanism
In this study, we interrogated the mechanism by which the immunosuppressant FTY720 mediates anticancer effects in oral squamous cell carcinoma (OSCC) cells. FTY720 differentially suppressed the viability of th...
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Article
Open AccessPleiotropic Effects of Myocardial MMP-9 Inhibition to Prevent Ventricular Arrhythmia
Observational studies have established a strong association between matrix metalloproteinase-9 (MMP-9) and ventricular arrhythmia. However, whether MMP-9 has a causal link to ventricular arrhythmia, as well as...
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Article
Open AccessRobustness of a Topologically Protected Surface State in a Sb2Te2Se Single Crystal
A topological insulator (TI) is a quantum material in a new class with attractive properties for physical and technological applications. Here we derive the electronic structure of highly crystalline Sb2Te2Se sin...
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Article
Open AccessPharmacological exploitation of the phenothiazine antipsychotics to develop novel antitumor agents–A drug repurposing strategy
Phenothiazines (PTZs) have been used for the antipsychotic drugs for centuries. However, some of these PTZs have been reported to exhibit antitumor effects by targeting various signaling pathways in vitro and in ...
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Article
Open AccessCHRNA7 Polymorphisms and Dementia Risk: Interactions with Apolipoprotein ε4 and Cigarette Smoking
α7 nicotinic acetylcholine receptor (α7nAChR, encoded by CHRNA7) is involved in dementia pathogenesis through cholinergic neurotransmission, neuroprotection and interactions with amyloid-β. Smoking promotes ather...