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  1. Article

    Open Access

    Surplus fatty acid synthesis increases oxidative stress in adipocytes and induces lipodystrophy

    Adipocytes are the primary sites for fatty acid storage, but the synthesis rate of fatty acids is very low. The physiological significance of this phenomenon remains unclear. Here, we show that surplus fatty a...

    Li Weng, Wen-Shuai Tang, Xu Wang, Yingyun Gong, Changqin Liu in Nature Communications (2024)

  2. Article

    Open Access

    Temperature-dependent interphase formation and Li+ transport in lithium metal batteries

    High-performance Li-ion/metal batteries working at a low temperature (i.e., <−20 °C) are desired but hindered by the sluggish kinetics associated with Li+ transport and charge transfer. Herein, the temperature-de...

    Suting Weng, **ao Zhang, Gao**g Yang, Simeng Zhang, Bingyun Ma in Nature Communications (2023)

  3. Article

    Open Access

    Enhancing human resilience beyond COVID-19-related stress: public responses to multi-benefits of home gardening

    The SARS-CoV-2 virus has caused a public health crisis globally. Against the backdrop of global resilience, studies have demonstrated the therapeutic value of home gardening as a measure to strengthen human he...

    Chen-Fa Wu, Luu Van Thong Trac, Szu-Hung Chen, Alisara Menakanit in Scientific Reports (2023)

  4. Article

    Open Access

    Association of different obesity patterns with hypertension in US male adults: a cross-sectional study

    Obesity is an important risk factor for hypertension. We aimed to investigate the association between different obesity patterns and hypertension risk in a large male population in the US. Male participants fr...

    Lu Chen, Jun Zhang, Nan Zhou, Jia-Yi Weng, Zheng-Yang Bao, Li-Da Wu in Scientific Reports (2023)

  5. Article

    Open Access

    Multifunctional solvent molecule design enables high-voltage Li-ion batteries

    Elevating the charging cut-off voltage is one of the efficient approaches to boost the energy density of Li-ion batteries (LIBs). However, this method is limited by the occurrence of severe parasitic reactions...

    Junbo Zhang, Haikuo Zhang, Suting Weng, Ruhong Li, Di Lu, Tao Deng in Nature Communications (2023)

  6. Article

    Open Access

    Tailoring polymer electrolyte ionic conductivity for production of low- temperature operating quasi-all-solid-state lithium metal batteries

    The stable operation of lithium-based batteries at low temperatures is critical for applications in cold climates. However, low-temperature operations are plagued by insufficient dynamics in the bulk of the el...

    Zhuo Li, Rui Yu, Suting Weng, Qinghua Zhang, Xuefeng Wang, **n Guo in Nature Communications (2023)

  7. Article

    Open Access

    Analysis of clinically relevant variants from ancestrally diverse Asian genomes

    Asian populations are under-represented in human genomics research. Here, we characterize clinically significant genetic variation in 9051 genomes representing East Asian, South Asian, and severely under-repre...

    Sock Hoai Chan, Yasmin Bylstra, **g **an Teo, Jyn Ling Kuan in Nature Communications (2022)

  8. Article

    Open Access

    Tackling realistic Li+ flux for high-energy lithium metal batteries

    Electrolyte engineering advances Li metal batteries (LMBs) with high Coulombic efficiency (CE) by constructing LiF-rich solid electrolyte interphase (SEI). However, the low conductivity of LiF disturbs Li+ diffus...

    Shuoqing Zhang, Ruhong Li, Nan Hu, Tao Deng, Suting Weng in Nature Communications (2022)

  9. No Access

    Article

    Long-term outcomes and prognostic factors in papillary thyroid microcarcinoma patients with distant metastases

    Distant metastasis from papillary thyroid microcarcinoma (PTMC) is extremely rare and the long-term outcomes and independent prognostic factors remain unclear. The present study aimed to investigate clinicopat...

    Huai-Yu Weng, Ting Yan, Wang-Wang Qiu, Chuang **, Li-Ying Hou, Zhi-Li Yang in Endocrine (2022)

  10. Article

    Open Access

    No association between alcohol consumption and pancreatic cancer even among individuals genetically susceptible to the carcinogenicity of alcohol

    Inconsistent results have been reported for the association between alcohol use and pancreatic cancer, particularly at low levels of alcohol consumption. Individuals genetically susceptible to the carcinogenic...

    Yan-Shen Shan, Li-Tzong Chen, Chih-Hsing Wu, Yin-Fan Chang in Scientific Reports (2021)

  11. Article

    Open Access

    Chia, a large annotated corpus of clinical trial eligibility criteria

    We present Chia, a novel, large annotated corpus of patient eligibility criteria extracted from 1,000 interventional, Phase IV clinical trials registered in ClinicalTrials.gov. This dataset includes 12,409 ann...

    Fabrício Kury, Alex Butler, Chi Yuan, Li-heng Fu, Yingcheng Sun, Hao Liu in Scientific Data (2020)

  12. Article

    Open Access

    Traditional versus blended CPR training program: A randomized controlled non-inferiority study

    Cardiopulmonary resuscitation (CPR) training and its quality are critical in improving the survival rate of cardiac arrest. This randomized controlled study investigated the efficacy of a newly developed CPR t...

    Cheng-Yu Chien, Shao-Yu Fang, Li-Heng Tsai, Shang-Li Tsai in Scientific Reports (2020)

  13. Article

    Open Access

    Author Correction: FTY720 Induces Autophagy-Associated Apoptosis in Human Oral Squamous Carcinoma Cells, in Part, through a Reactive Oxygen Species/Mcl-1-Dependent Mechanism

    An amendment to this paper has been published and can be accessed via a link at the top of the paper.

    Li-Yuan Bai, Chang-Fang Chiu, Shih-Jiuan Chiu, Po-Chen Chu in Scientific Reports (2020)

  14. Article

    Open Access

    Chiral fermion reversal in chiral crystals

    In materials chiral fermions such as Weyl fermions are characterized by nonzero chiral charges, which are singular points of Berry curvature in momentum space. Recently, new types of chiral fermions beyond Wey...

    Hang Li, Sheng Xu, Zhi-Cheng Rao, Li-Qin Zhou, Zhi-Jun Wang in Nature Communications (2019)

  15. Article

    Open Access

    Persistence and continuous evolution of the human respiratory syncytial virus in northern Taiwan for two decades

    The study aimed to characterize the molecular epidemiology, phylogenetic relationship, and population dynamics of the G protein gene in clinical respiratory syncytial virus (RSV) strains isolated from northern...

    Hsin Chi, Kuang-Liang Hsiao, Li-Chuan Weng, Chang-Pan Liu in Scientific Reports (2019)

  16. Article

    Open Access

    Cross-ethnic meta-analysis identifies association of the GPX3-TNIP1 locus with amyotrophic lateral sclerosis

    Cross-ethnic genetic studies can leverage power from differences in disease epidemiology and population-specific genetic architecture. In particular, the differences in linkage disequilibrium and allele freque...

    Beben Benyamin, Ji He, Qiongyi Zhao, Jacob Gratten, Fleur Garton in Nature Communications (2017)

  17. Article

    Open Access

    FTY720 Induces Autophagy-Associated Apoptosis in Human Oral Squamous Carcinoma Cells, in Part, through a Reactive Oxygen Species/Mcl-1-Dependent Mechanism

    In this study, we interrogated the mechanism by which the immunosuppressant FTY720 mediates anticancer effects in oral squamous cell carcinoma (OSCC) cells. FTY720 differentially suppressed the viability of th...

    Li-Yuan Bai, Chang-Fang Chiu, Shih-Jiuan Chiu, Po-Chen Chu in Scientific Reports (2017)

  18. Article

    Open Access

    Pleiotropic Effects of Myocardial MMP-9 Inhibition to Prevent Ventricular Arrhythmia

    Observational studies have established a strong association between matrix metalloproteinase-9 (MMP-9) and ventricular arrhythmia. However, whether MMP-9 has a causal link to ventricular arrhythmia, as well as...

    Ching-Hui Weng, Fa-Po Chung, Yao-Chang Chen, Shien-Fong Lin in Scientific Reports (2016)

  19. Article

    Open Access

    Robustness of a Topologically Protected Surface State in a Sb2Te2Se Single Crystal

    A topological insulator (TI) is a quantum material in a new class with attractive properties for physical and technological applications. Here we derive the electronic structure of highly crystalline Sb2Te2Se sin...

    Chao-Kuei Lee, Cheng-Maw Cheng, Shih-Chang Weng, Wei-Chuan Chen in Scientific Reports (2016)

  20. Article

    Open Access

    Pharmacological exploitation of the phenothiazine antipsychotics to develop novel antitumor agents–A drug repurposing strategy

    Phenothiazines (PTZs) have been used for the antipsychotic drugs for centuries. However, some of these PTZs have been reported to exhibit antitumor effects by targeting various signaling pathways in vitro and in ...

    Chia-Hsien Wu, Li-Yuan Bai, Ming-Hsui Tsai, Po-Chen Chu in Scientific Reports (2016)

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