13 Result(s)
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Article
Open AccessDistinct epigenetic modulation of differentially expressed genes in the adult mouse brain following prenatal exposure to low-dose bisphenol A
Bisphenol A (BPA) is a common component in the manufacture of daily plastic consumer goods. Recent studies have suggested that prenatal exposure to BPA can increase the susceptibility of offspring to mental il...
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YEATS2 regulates the activation of TAK1/NF-κB pathway and is critical for pancreatic ductal adenocarcinoma cell survival
The prognosis of pancreatic ductal adenocarcinoma (PDAC) is poor despite diagnostic progress and new chemotherapeutic regimens. Constitutive activation of NF-κB is frequently observed in PDAC. In this study, w...
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Open AccessRetraction Note: Upregulation of OSBPL3 by HIF1A promotes colorectal cancer progression through activation of RAS signaling pathway
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Article
Degradation kinetics and performances of poly(lactic acid) films in artificial seawater
Used poly(lactic acid) (PLA) films as the research object, the degradation kinetics equation was established through the degradation experiments of samples in artificial seawater at 60, 70, 80 and 90 °C, and t...
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Open AccessRETRACTED ARTICLE: Upregulation of OSBPL3 by HIF1A promotes colorectal cancer progression through activation of RAS signaling pathway
Oxysterol-binding protein like protein 3 (OSBPL3) has been shown involving in the development of several human cancers. However, the relationship between OSBPL3 and colorectal cancer (CRC), particularly the ro...
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Article
Open Access2-aminopurine suppresses the TGF-β1-induced epithelial–mesenchymal transition and attenuates bleomycin-induced pulmonary fibrosis
The epithelial–mesenchymal transition (EMT) is a multifunctional cell process involved in the pathogenesis of numerous conditions, including fibrosis and cancer. Idiopathic pulmonary fibrosis (IPF) is a progre...
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Article
Effect of side chain length on intrahelical interactions between carboxylate- and guanidinium-containing amino acids
The charge-containing hydrophilic functionalities of encoded charged amino acids are linked to the backbone via different numbers of hydrophobic methylenes, despite the apparent electrostatic nature of protein...
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Article
Enhancing catalytic activity of a hybrid xylanase through single substitution of Leu to Pro near the active site
A modified error-prone PCR and high-throughout screening system based on 96-well plate were employed to improve catalytic activity of a hybrid xylanase (ATx). The mutant (FSI-A124) with enhanced activity was f...
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Enhanced Expression of Resistin-like Molecule Beta in Human Colon Cancer and Its Clinical Significance
Previous studies have indicated that resistin-like molecule beta (RELMβ), an intestinal goblet cell-specific protein, is markedly increased in the intestinal tumors of min mice and over-expressed in a human colon...
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Over-expressed estrogen receptor-α up-regulates hTNF-α gene expression and down-regulates β-catenin signaling activity to induce the apoptosis and inhibit proliferation of LoVo colon cancer cells
Epidemiologic studies reported that the prevalence of hereditary non-polyposis colon cancer (HNPCC) in male is about 1.5-fold higher than that in female. Decreases in circulatory estrogen (E2) have been reported ...
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Article
Selection of biochemical mutants of Aspergillus niger with enhanced extracellular ribonuclease production
Combined with u.v. irradiation and the nitrosoguanidine method, selection of biochemical mutants resistant to metabolic inhibitors (2-deoxy-D-glucose, antimycin A, sodium orthovanadate and sodium azide) was a ...
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Screening and Mutagenesis of Aspergillus niger for the Improvement of Glucose-6-Phosphate Dehydrogenase Production
The Aspergillus niger strain ZBY-7 was selected as the original strain of glucose-6-phosphate dehydrogenase production. After mutagenesis of the strain by means of UV irradiation and nitrosoguanidine, mutants of
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Article
Optimization of glucose oxidase production by Aspergillus niger in a benchtop bioreactor using response surface methodology
Response surface methodology (RSM) was applied to optimize the speed of agitation and the rate of aeration for the maximum production of glucose oxidase (GOD) by Aspergillus niger. A 22 central composite design u...
