216 Result(s)
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Article
Open AccessWhole-genome analysis informs breast cancer response to aromatase inhibition
To correlate the variable clinical features of oestrogen-receptor-positive breast cancer with somatic alterations, we studied pretreatment tumour biopsies accrued from patients in two studies of neoadjuvant ar...
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Open AccessGlobally homochiral assembly of two-dimensional molecular networks triggered by co-absorbers
Understanding the chirality induction and amplification processes, and the construction of globally homochiral surfaces, represent essential challenges in surface chirality studies. Here we report the inductio...
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Open AccessIncrease in penguin populations during the Little Ice Age in the Ross Sea, Antarctica
Penguins are an important seabird species in Antarctica and are sensitive to climate and environmental changes. Previous studies indicated that penguin populations increased when the climate became warmer and ...
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Open AccessAn unprecedented (3,4,24)-connected heteropolyoxozincate organic framework as heterogeneous crystalline Lewis acid catalyst for biodiesel production
A novel 3D hexadecanuclear heteropolyoxozincate organic framework, IFMC-200, has been successfully synthesized based on a late transition metal-oxygen cluster. IFMC-200 not only represents the first example of...
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Open AccessHigh-Resolution Melting Analysis for accurate detection of BRAF mutations: a systematic review and meta-analysis
The high-resolution melting curve analysis (HRMA) might be a good alternative method for rapid detection of BRAF mutations. However, the accuracy of HRMA in detection of BRAF mutations has not been systematica...
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Ultralow thermal conductivity and high thermoelectric figure of merit in SnSe crystals
The main obstacle to improving the thermoelectric efficiency of a material arises from the common interdependence of electrical and thermal conductivity, whereas one ideally wants to raise the former while low...
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Article
Relative motions between left flipper and dorsal fin domains favour P2X4 receptor activation
Channel gating in response to extracellular ATP is a fundamental process for the physiological functions of P2X receptors. Here we identify coordinated allosteric changes in the left flipper (LF) and dorsal fi...
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Open AccessInterferon regulatory factor 9 is critical for neointima formation following vascular injury
Interferon regulatory factor 9 (IRF9) has various biological functions and regulates cell survival; however, its role in vascular biology has not been explored. Here we demonstrate a critical role for IRF9 in ...
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Open AccessGenomewide Analysis of Rat Periaqueductal Gray-Dorsal Horn Reveals Time-, Region- and Frequency-Specific mRNA Expression Changes in Response to Electroacupuncture Stimulation
Electroacupuncture (EA) has been widely applied for illness prevention, treatment or rehabilitation in the clinic, especially for pain management. However, the molecular events that induce these changes remain...
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Open AccessThe complex jujube genome provides insights into fruit tree biology
The jujube (Ziziphus jujuba Mill.), a member of family Rhamnaceae, is a major dry fruit and a traditional herbal medicine for more than one billion people. Here we present a high-quality sequence for the complex ...
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Open AccessBacterial dynamics within the mucus, tissue and skeleton of the coral Porites lutea during different seasons
Investigation of the response of coral microbial communities to seasonal ecological environment at the microscale will advance our understanding of the relationship between coral-associated bacteria community ...
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Open AccessThe anti-fibrotic effects of mesenchymal stem cells on irradiated lungs via stimulating endogenous secretion of HGF and PGE2
Radiation-induced pulmonary fibrosis is a common disease and has a poor prognosis owing to the progressive breakdown of gas exchange regions in the lung. Recently, a novel strategy of administering mesenchymal...
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Open AccessA Lower pH Value Benefits Regeneration of Trichosanthes kirilowii by Somatic Embryogenesis, Involving Rhizoid Tubers (RTBs), a Novel Structure
A new approach was established for the regeneration of Trichosanthes kirilowii from root, stem and leaf explants by somatic embryogenesis (SE), involving a previously unreported SE structure, rhizoid tubers (RTBs...
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Open AccessTranscriptome comparison of the sex pheromone glands from two sibling Helicoverpa species with opposite sex pheromone components
Differences in sex pheromone component can lead to reproductive isolation. The sibling noctuid species, Helicoverpa armigera and Helicoverpa assulta, share the same two sex pheromone components, Z9-16:Ald and Z11...
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Correction: Corrigendum: Interferon regulatory factor 9 is critical for neointima formation following vascular injury
Nature Communications 5: Article number: 5160 (2014); Published: 16 October 2014; Updated: 01 April 2015 The value of the relative luciferase activity of RASMCs infected with AdshIRF9 and AdshSIRT1 in Suppleme...
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Open AccessThe Clinical Features and Bacteriological Characterizations of Bone and Joint Tuberculosis in China
Bone and Joint tuberculosis (BJTB) constitutes about 10% of total extra-pulmonary TB cases. Since the BJTB is a paucibacillary condition, there has been no systematic study on the bacterial characterization, e...
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Open AccessIdentification of the gene defect responsible for severe hypercholesterolaemia using whole-exome sequencing
Familial hypercholesterolaemia (FH) is a serious genetic metabolic disease. We identified a specific family in which the proband had typical homozygous phenotype of FH, but couldn’t detect any mutations in usu...
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Open AccessIntraventricular Hemorrhage and Early Hematoma Expansion in Patients with Intracerebral Hemorrhage
Intraventricular hemorrhage is associated with poor functional outcomes in patients with intracerebral hemorrhage (ICH). We aimed to investigate the association between intraventricular hemorrhage and early he...
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Open AccessA systematic analysis of human lipocalin family and its expression in esophageal carcinoma
The lipocalin proteins (lipocalins) are a large family of small proteins characterized by low sequence similarity and highly conserved crystal structures. Lipocalins have been found to play important roles in ...
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Open AccessRapid and Sensitive Isothermal Detection of Nucleic-acid Sequence by Multiple Cross Displacement Amplification
We have devised a novel amplification strategy based on isothermal strand-displacement polymerization reaction, which was termed multiple cross displacement amplification (MCDA). The approach employed a set of...
