61 Result(s)
within
Li zhu
Science, multidisciplinary
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Article
Open AccessA dataset of hidden small non-coding RNA in the testis of heat-stressed models revealed by Pandora-seq
Infertility, a worldwide reproductive health concern, impacts approximately one in five couples. Male infertility, stemming from spermatogenic dysfunction and reduced sperm quality, stands as a primary factor ...
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Article
Open AccessNetwork pharmacological prediction of the mechanism of action of Shen-Zhu-Lian-Bai Decoction in the treatment of ulcerative colitis
The incidence of ulcerative colitis (UC) is on the rise globally. Shen-Zhu-Lian-Bai decoction (SZLBD) can relieve the clinical symptoms of UC. This study aimed to investigate the underlying molecular mechanism...
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Open AccessInvestigating the causal relationship between thyroid dysfunction diseases and osteoporosis: a two-sample Mendelian randomization analysis
The prevalence of thyroid dysfunction diseases (TDFDs) and osteoporosis (OP) is high. Previous studies have indicated a potential association between TDFDs and OP, yet the causal direction remains unclear. Thi...
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Article
Open AccessBaicalin enhances the chemotherapy sensitivity of oxaliplatin-resistant gastric cancer cells by activating p53-mediated ferroptosis
Gastric cancer is one of the most common malignant tumors, and chemotherapy is the main treatment for advanced gastric cancer. However, chemotherapy resistance leads to treatment failure and poor prognosis in ...
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Article
Open AccessEffect of crystal facets in plasmonic catalysis
While the role of crystal facets is well known in traditional heterogeneous catalysis, this effect has not yet been thoroughly studied in plasmon-assisted catalysis, where attention has primarily focused on pl...
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Article
Open AccessSelective ensemble method for anomaly detection based on parallel learning
Anomaly detection is a highly important task in the field of data analysis. Traditional anomaly detection approaches often strongly depend on data size, structure and features, while introducing the idea of en...
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Article
Open AccessIntranasal mask for protecting the respiratory tract against viral aerosols
The spread of many infectious diseases relies on aerosol transmission to the respiratory tract. Here we design an intranasal mask comprising a positively-charged thermosensitive hydrogel and cell-derived micro...
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Article
Inhaled SARS-CoV-2 vaccine for single-dose dry powder aerosol immunization
The COVID-19 pandemic has fostered major advances in vaccination technologies1–4; however, there are urgent needs for vaccines that induce mucosal immune responses and for single-dose, non-invasive administration
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Article
Open AccessMultinomial machine learning identifies independent biomarkers by integrated metabolic analysis of acute coronary syndrome
A multi-class classification model for acute coronary syndrome (ACS) remains to be constructed based on multi-fluid metabolomics. Major confounders may exert spurious effects on the relationship between metabo...
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Article
Open AccessDynamic changes in the transcriptome of tRNA-derived small RNAs related with fat metabolism
The prevalence of obesity and overweight is steadily rising, posing a significant global challenge for humanity. The fundamental cause of obesity and overweight lies in the abnormal accumulation of adipose tis...
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Article
Open AccessCharacterization of two O-methyltransferases involved in the biosynthesis of O-methylated catechins in tea plant
Tea is known for having a high catechin content, with the main component being (−)-epigallocatechin gallate (EGCG), which has significant bioactivities, including potential anti-cancer and anti-inflammatory ac...
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Article
Open AccessDynamic chromatin architecture of the porcine adipose tissues with weight gain and loss
Using an adult female miniature pig model with diet-induced weight gain/weight loss, we investigated the regulatory mechanisms of three-dimensional (3D) genome architecture in adipose tissues (ATs) associated ...
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Article
Open AccessVertically integrated spiking cone photoreceptor arrays for color perception
The cone photoreceptors in our eyes selectively transduce the natural light into spiking representations, which endows the brain with high energy-efficiency color vision. However, the cone-like device with col...
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Article
A Conceptual Framework for Achieving Sustainable Building Through Compressed Earth Block: a Case of Ouagadougou, Burkina Faso
The concept and importance of sustainability and sustainable development are gaining critical recognition and attention around the world. As most develo** countries are ailing with limited resources concerni...
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Article
Open AccessFederated learning via over-the-air computation in IRS-assisted UAV communications
Intelligent reflective surface (IRS) and unmanned aerial vehicle (UAV) communication are two key technologies in the sixth generation of mobile communication (6G). In this paper, IRS is equipped on UAV to form...
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Article
Open AccessQuantum structural fluxion in superconducting lanthanum polyhydride
The discovery of 250-kelvin superconducting lanthanum polyhydride under high pressure marked a significant advance toward the realization of a room‐temperature superconductor. X-ray diffraction (XRD) studies r...
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Open AccessManipulation of sterol homeostasis for the production of 24-epi-ergosterol in industrial yeast
Brassinolide (BL) is the most biologically active compound among natural brassinosteroids. However, the agricultural applications are limited by the extremely low natural abundance and the scarcity of syntheti...
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Open AccessStructural insights into mechanism and specificity of the plant protein O-fucosyltransferase SPINDLY
Arabidopsis glycosyltransferase family 41 (GT41) protein SPINDLY (SPY) plays pleiotropic roles in plant development. Despite the amino acid sequence is similar to human O-GlcNAc transferase, Arabidopsis SPY has b...
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Article
Open AccessESR1 mutant breast cancers show elevated basal cytokeratins and immune activation
Estrogen receptor alpha (ER/ESR1) is frequently mutated in endocrine resistant ER-positive (ER+) breast cancer and linked to ligand-independent growth and metastasis. Despite the distinct clinical features of ESR...
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Open AccessThe association of complex genetic background with the prognosis of acute leukemia with ambiguous lineage
Acute leukemia with ambiguous lineage (ALAL) is a rare and highly aggressive malignancy with limited molecular characterization and therapeutic recommendations. In this study, we retrospectively analyzed 1635 ...
