8 Result(s)
within
Li zhu
English
Human Genetics
-
Article
Open AccessIdentification of potential diagnostic biomarkers of atherosclerosis based on bioinformatics strategy
Atherosclerosis is the main pathological change in atherosclerotic cardiovascular disease, and its underlying mechanisms are not well understood. The aim of this study was to explore the hub genes involved in ...
-
Article
Open AccessTDP-43 regulates cancer-associated microRNAs
Aberrant regulation of miRNA genes contributes to pathogenesis of a wide range of human diseases, including cancer. The TAR DNA binding protein 43 (TDP-43), a RNA/DNA binding protein associated with neurodegen...
-
Article
Open AccessA new method for quantifying mitochondrial axonal transport
Axonal transport of mitochondria is critical for neuronal survival and function. Automatically quantifying and analyzing mitochondrial movement in a large quantity remain challenging. Here, we report an effici...
-
Article
Open AccessMiR-130a regulates neurite outgrowth and dendritic spine density by targeting MeCP2
MicroRNAs (miRNAs) are critical for both development and function of the central nervous system. Significant evidence suggests that abnormal expression of miRNAs is associated with neurodevelopmental disorders...
-
Article
Open AccessUSP33, a new player in lung cancer, mediates Slit-Robo signaling
Ubiquitin specific protease 33 (USP33) is a multifunctional protein regulating diverse cellular processes. The expression and role of USP33 in lung cancer remain unexplored. In this study, we show that USP33 i...
-
Article
AMPK interacts with DSCAM and plays an important role in Netrin-1 induced neurite outgrowth
Down syndrome cell adhesion molecule (DSCAM) acts as a netrin-1 receptor and mediates attractive response of axons to netrin-1 in neural development. However, the signaling mechanisms of netrin-DSCAM remain un...
-
Article
Dscam mutation leads to hydrocephalus and decreased motor function
The nervous system is one of the most complicated organ systems in invertebrates and vertebrates. Down syndrome cell adhesion molecule (DSCAM) of the immunoglobulin (Ig) superfamily is expressed widely in the ...
-
Article
Expression of human FUS protein in Drosophila leads to progressive neurodegeneration
Mutations in the Fused in sarcoma/Translated in liposarcoma gene (FUS/TLS, FUS) have been identified among patients with amyotrophic lateral sclerosis (ALS). FUS protein aggregation is a major pathological hallma...
