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The regulation of skeletal muscle fiber-type composition by betaine is associated with NFATc1/MyoD

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  1. Article

    A novel STAT3 inhibitor negatively modulates platelet activation and aggregation

    The signal transducer and activator of transcription 3 (STAT3) plays a critical role in platelet functions. This study sought to understand the effects of the STAT3 inhibitor SC99 on platelet activation and ag...

    Zhuan Xu, Yu-jia Xu, Ya-nan Hao, Li-jie Ren, Zu-bin Zhang… in Acta Pharmacologica Sinica (2017)

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  2. Article

    Asiatic acid, a pentacyclic triterpene in Centella asiatica, attenuates glutamate-induced cognitive deficits in mice and apoptosis in SH-SY5Y cells

    To investigate whether asiatic acid (AA), a pentacyclic triterpene in Centella asiatica, exerted neuroprotective effects in vitro and in vivo, and to determine the underlying mechanisms.

    Min-fang Xu, Yu-yun **ong, Jian-kang Liu, **-jun Qian… in Acta Pharmacologica Sinica (2012)

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  3. Article

    Combination of fluvastatin and losartan relieves atherosclerosis and macrophage infiltration in atherosclerotic plaques in rabbits

    To investigate whether the combination of fluvastatin and losartan synergistically relieve atherosclerosis and plaque inflammation induced by a high-cholesterol diet in rabbits.

    Ya-pei Yang, Qiu-li Dong, Xu-hong Zhang, Yue-hui Zhang… in Acta Pharmacologica Sinica (2011)

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  4. Article

    Triptolide inhibits the proliferation of cells from lymphocytic leukemic cell lines in association with downregulation of NF-κB activity and miR-16-1*

    To examine the effects of triptolide (TPL) on T-cell leukemia cells and identify their underlying mechanisms.

    Hai-tao Meng, Li Zhu, Wan-mao Ni, Liang-shun You, Jie **… in Acta Pharmacologica Sinica (2011)

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  5. Article

    Genome-wide analysis of microRNA and mRNA expression signatures in hydroxycamptothecin-resistant gastric cancer cells

    To investigate the involvement of microRNAs (miRNAs) in intrinsic drug resistance to hydroxycamptothecin (HCPT) of six gastric cancer cell lines (BGC-823, SGC-7901, MGC-803, HGC-27, NCI-N87, and AGS).

    Xue-mei Wu, **ang-qiang Shao, **an-xin Meng, **ao-na Zhang… in Acta Pharmacologica Sinica (2011)

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  6. Article

    Ginsenoside Rb1 protects cardiomyocytes against CoCl2-induced apoptosis in neonatal rats by inhibiting mitochondria permeability transition pore opening

    To investigate whether mitochondria permeability transition pore (mPTP) opening was involved in ginsenoside Rb1 (Gs-Rb1) induced anti-hypoxia effects in neonatal rat cardiomyocytes ex vivo.

    Hong-liang Kong, Zhan-quan Li, Ying-jun Zhao, Shu-mei Zhao… in Acta Pharmacologica Sinica (2010)

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  7. Article

    Open Access

    The Evolving Systemic and Local Biomarker Milieu at Different Stages of Disease Progression in Rat Adjuvant-Induced Arthritis

    Rats with adjuvant-induced arthritis (AIA) were necropsied on 14 occasions during preclinical, acute clinical and chronic clinical stages of AIA progression to characterize local (joint protein extracts) and s...

    Marina Stolina, Brad Bolon, Scot Middleton, Denise Dwyer… in Journal of Clinical Immunology (2009)

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