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Article
Open AccessA Multi-strategy Improved Grasshopper Optimization Algorithm for Solving Global Optimization and Engineering Problems
This paper presents a multi-strategy improved grasshopper optimization algorithm (MSIGOA), which aims to address the shortcomings of the grasshopper optimization algorithm (GOA), including its slow convergence...
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Article
Open AccessTelomere-to-telomere Citrullus super-pangenome provides direction for watermelon breeding
To decipher the genetic diversity within the cucurbit genus Citrullus, we generated telomere-to-telomere (T2T) assemblies of 27 distinct genotypes, encompassing all seven Citrullus species. This T2T super-pangeno...
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Article
Open AccessGeneral negative pressure annealing approach for creating ultra-high-loading single atom catalyst libraries
Catalyst systems populated by high-density single atoms are crucial for improving catalytic activity and selectivity, which can potentially maximize the industrial prospects of heterogeneous single-atom cataly...
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Article
Open AccessPromoter profiles in plasma CfDNA exhibits a potential utility of predicting the efficacy of neoadjuvant chemotherapy in breast cancer patients
Gene expression profiles in breast tissue biopsies contain information related to chemotherapy efficacy. The promoter profiles in cell-free DNA (cfDNA) carrying gene expression information of the original tiss...
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Article
Open AccessSPARC overexpression in allogeneic adipose-derived mesenchymal stem cells in dog dry eye model induced by benzalkonium chloride
Nowadays, companion and working dogs hold significant social and economic importance. Dry eye, also known as dry keratoconjunctivitis (KCS), a common disease in ophthalmology, can readily impact a dog’s workin...
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Article
Open AccessAssociation Between Myopia and Pupil Diameter in Preschoolers: Evidence from a Machine Learning Approach Based on a Real-World Large-Scale Dataset
Previous studies have explored the connections between various ocular biological parameters with myopia. Our previous study also found that pupil data can predict the myopic progression during the intervention...
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Article
Open AccessiPSCs chondrogenic differentiation for personalized regenerative medicine: a literature review
Cartilage, an important connective tissue, provides structural support to other body tissues, and serves as a cushion against impacts throughout the body. Found at the end of the bones, cartilage decreases fri...
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Article
Open AccessGinsenoside Rg3 attenuates myocardial ischemia/reperfusion-induced ferroptosis via the keap1/Nrf2/GPX4 signaling pathway
Ginsenoside Rg3 is a component of ginseng that protects against myocardial ischemia/reperfusion (MI/R) injury. Ferroptosis is a new form of cell death characterized by oxidative damage to phospholipids. The pu...
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Open AccessApplication of the process-based teaching based on SPARK case database in the practice teaching of radiology in the musculoskeletal system for undergraduate medical students
Process-based teaching is a new education model. SPARK case database is a free medical imaging case database. This manuscript aimed to explore the application of the process-based teaching based on SPARK case ...
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Article
Open AccessIFIT1 + neutrophil is a causative factor of immunosuppressive features of poorly cohesive carcinoma (PCC)
The importance of the immune microenvironment in poorly cohesive carcinoma (PCC) has been highlighted due to its limited response rate to conventional therapy and emerging treatment resistance. A combination o...
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Article
Open AccessSHH induces macrophage oxidative phosphorylation and efferocytosis to promote scar formation
Excessive scar formation such as hypertrophic scars and keloids, resulting from trauma or surgical procedures, present a widespread concern for causing disfigurement, discomfort, and functional limitations. Ma...
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Article
Open AccessA chromosome-level genome assembly and annotation of the medicinal plant Lepidium apetalum
As a traditional Chinese medicine, Lepidium apetalum is commonly used for purging the lung, relieving dyspnea, alleviating edema, and has the significant pharmacological effects on cardiovascular disease, hyperli...
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Article
Open AccessThe vaginal microbial signatures of preterm birth woman
To explore the differences of vaginal microbes in women with preterm birth (PTB), and to construct prediction model. We searched for articles related to vaginal microbiology in preterm women and obtained four ...
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Article
Open AccessMinimally invasive versus open ileal ureter with ileocystoplasty: comparative outcomes and 5-year experience
To present the experience of ileal ureter with ileocystoplasty (IUC), and compare the outcomes of IUC in minimally invasive procedures to open procedures.
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Article
Open AccessExosomal circSIPA1L3-mediated intercellular communication contributes to glucose metabolic reprogramming and progression of triple negative breast cancer
Breast cancer is the most common malignant tumor, and metastasis remains the major cause of poor prognosis. Glucose metabolic reprogramming is one of the prominent hallmarks in cancer, providing nutrients and ...
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Article
Open AccessEffectiveness of risk-based caries management among Chinese preschool children: a randomized controlled single-blind trial
Early childhood caries (ECC) remain a serious oral health problem on a global scale. Risk-based caries management (RBCM) implemented in some parts of the world has been effective in preventing ECC. However, th...
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Open AccessThe residual risk of inflammation and remnant cholesterol in acute coronary syndrome patients on statin treatment undergoing percutaneous coronary intervention
Residual risk assessment for acute coronary syndrome (ACS) patients after sufficient medical management remains challenging. The usefulness of measuring high-sensitivity C-reactive protein (hsCRP) and remnant ...
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Article
Open AccessPrediction of the axillary lymph-node metastatic burden of breast cancer by 18F-FDG PET/CT-based radiomics
The axillary lymph-node metastatic burden is closely associated with treatment decisions and prognosis in breast cancer patients. This study aimed to explore the value of 18F-fluorodeoxyglucose (18F-FDG) positron...
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Article
Open AccessA harmonized global gridded transpiration product based on collocation analysis
Transpiration (T) is pivotal in the global water cycle, responding to soil moisture, atmospheric stress, climate changes, and human impacts. Therefore, establishing a reliable global transpiration dataset is e...
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Article
Open AccessAdvancing the In-Class Dialogic Quality: Develo** an Artificial Intelligence-Supported Framework for Classroom Dialogue Analysis
The development of artificial intelligence (AI) significantly improves the effectiveness of classroom dialogue systems, but their integration into the learning environment remains challenging. To address this ...
