1,819 Result(s)

Article

Telomere-to-telomere Citrullus super-pangenome provides direction for watermelon breeding

To decipher the genetic diversity within the cucurbit genus Citrullus, we generated telomere-to-telomere (T2T) assemblies of 27 distinct genotypes, encompassing all seven Citrullus species. This T2T super-pangeno...

Yilin Zhang, Mingxia Zhao, **gsheng Tan, Minghan Huang, **ao Chu… in Nature Genetics (2024)

Article

Unsupervised representation learning on high-dimensional clinical data improves genomic discovery and prediction

Although high-dimensional clinical data (HDCD) are increasingly available in biobank-scale datasets, their use for genetic discovery remains challenging. Here we introduce an unsupervised deep learning model, ...

Taedong Yun, Justin Cosentino, Babak Behsaz, Zachary R. McCaw… in Nature Genetics (2024)

Article

Positive feedback loop of c-myc/XTP6/NDH2/NF-κB to promote malignant progression in glioblastoma

Recent studies have highlighted the significant role of the NF-κB signaling pathway in the initiation and progression of cancer. Furthermore, long noncoding RNAs (lncRNAs) have been identified as pivotal regul...

Feng **ao, Hong Zhu, Yun Guo… in Journal of Experimental & Clinical Cancer … (2024)

Article

3D airway geometry analysis of factors in airway navigation failure for lung nodules

This study aimed to quantitatively reveal contributing factors to airway navigation failure during radial probe endobronchial ultrasound (R-EBUS) by using geometric analysis in a three-dimensional (3D) space a...

Hwan-ho Cho, Junsu Choe, Jonghoon Kim, Yoo ** Oh, Hyun** Park… in Cancer Imaging (2024)

Article

Identification and validation of tumor-specific T cell receptors from tumor infiltrating lymphocytes using tumor organoid co-cultures

T cell receptor-engineered T cells (TCR-Ts) therapy is promising for cancer immunotherapy. Most studies have focused on identifying tumor-specific T cell receptors (TCRs) through predicted tumor neoantigens. H...

Zhilang Li, Lisha Ma, Zhaoya Gao, **ya Wang, Xuan Che… in Cancer Immunology, Immunotherapy (2024)

Article

CCL11/CCR3-dependent eosinophilia alleviates malignant pleural effusions and improves prognosis

Malignant pleural effusion (MPE) is a common occurrence in advanced cancer and is often linked with a poor prognosis. Eosinophils were reported to involve in the development of MPE. However, the role of eosino...

Min Zhang, Lixia **a, Wenbei Peng, Guogang **e, Fei Li… in npj Precision Oncology (2024)

Article

The landscape of RNA-chromatin interaction reveals small non-coding RNAs as essential mediators of leukemia maintenance

RNA constitutes a large fraction of chromatin. Spatial distribution and functional relevance of most of RNA-chromatin interactions remain unknown. We established a landscape analysis of RNA-chromatin interacti...

Haiyang Yun, Julian Zoller, Fengbiao Zhou, Christian Rohde, Yi Liu… in Leukemia (2024)

Article

WZ-3146 acts as a novel small molecule inhibitor of KIF4A to inhibit glioma progression by inducing apoptosis

Glioma is considered the most common primary malignant tumor of the central nervous system. Although traditional treatments have not achieved satisfactory outcomes, recently, targeted therapies for glioma have...

Tao Yan, Qing Jiang, Guangpu Ni, Haofeng Ma, Yun Meng… in Cancer Cell International (2024)

Article

CSRP1 gene: a potential novel prognostic marker in acute myeloid leukemia with implications for immune response

Acute myeloid leukemia, constituting a majority of leukemias, grapples with a 24% 5-year survival rate. Recent strides in research have unveiled fresh targets for drug therapies. LIM-only, a pivotal transcript...

Chunxia Zhao, Yulu Wang, Huan Wang, Amit Sharma, Yun Wu… in Discover Oncology (2024)

Article

Publisher Correction: Cell-intrinsic and microenvironmental determinants of metastatic colonization

Arthur W. Lambert, Yun Zhang, Robert A. Weinberg in Nature Cell Biology (2024)

Article

Evaluating the immunologically “cold” tumor microenvironment after treatment with immune checkpoint inhibitors utilizing PET imaging of CD4 + and CD8 + T cells in breast cancer mouse models

Immune-positron emission tomography (PET) imaging with tracers that target CD8 and granzyme B has shown promise in predicting the therapeutic response following immune checkpoint blockade (ICB) in immunologica...

Yun Lu, Hailey A. Houson, Carlos A. Gallegos, Alessandro Mascioni… in Breast Cancer Research (2024)

Article

A novel surgical scheme for hepatectomy in hepatocellular carcinoma patients with clinically significant portal hypertension

Clinically significant portal hypertension (CSPH) seriously affects the feasibility and safety of surgical treatment for hepatocellular carcinoma (HCC) patients. The aim of this study was to establish a new su...

Jia-zhou Ye, Hua-ze Lu, Can Zeng, Guo Lei, **ao-bo Wang, Jie Chen, Tao Bai… in BMC Cancer (2024)

Article

Individualized dynamic frailty-tailored therapy (DynaFiT) in elderly patients with newly diagnosed multiple myeloma: a prospective study

It remains a substantial challenge to balance treatment efficacy and toxicity in geriatric patients with multiple myeloma (MM), primarily due to the dynamic nature of frailty. Here, we conducted a prospective ...

Yingjie Zhang, **nyue Liang, Weiling Xu, **ngcheng Yi… in Journal of Hematology & Oncology (2024)

Article

Correction: Inhibition of MTA1 by ERα contributes to protection hepatocellular carcinoma from tumor proliferation and metastasis

Lei Deng, Hui Yang, Junwei Tang, Zhe Lin… in Journal of Experimental & Clinical Cancer … (2024)

Article

First-line hepatic arterial infusion chemotherapy plus lenvatinib and PD-(L)1 inhibitors versus systemic chemotherapy alone or with PD-(L)1 inhibitors in unresectable intrahepatic cholangiocarcinoma

Limited treatment options exist for unresectable intrahepatic cholangiocarcinoma (ICC), with systemic chemotherapy (SC) serving as the primary approach. This study aimed to assess the effectiveness of first-li...

Yan-Song Lin, Shuo Li, **a Yang… in Journal of Cancer Research and Clinical On… (2024)