23 Result(s)

Article

CD7 targeted “off-the-shelf” CAR-T demonstrates robust in vivo expansion and high efficacy in the treatment of patients with relapsed and refractory T cell malignancies

T-cell acute lymphoblastic leukemia (T-ALL) represents an area of highly unmet medical needs. Once relapsed, patients have limited treatment options and poor prognosis. T-ALL antigens such as CD7 is extensivel...

Shiqi Li, **nxin Wang, Lin Liu, Jia Liu, Jun Rao, Zhongtao Yuan, Li Gao, Yu Li… in Leukemia (2023)

Article

HIF1α-mediated transactivation of WTAP promotes AML cell proliferation via m⁶A-dependent stabilization of KDM4B mRNA

Hypoxia inducible factor 1α (HIF1α) is abnormally overexpressed in t(8;21) acute myeloid leukemia (AML) and functions as an oncogene through transactivating DNA methyltransferase 3 alpha leading to DNA hyperme...

Yang-Liu Shao, Yu-Qing Li, Meng-Yue Li, Li-Li Wang, Hui-Sheng Zhou… in Leukemia (2023)

Article

A prognostic survival nomogram for persons with extra-nodal natural killer-/T-cell lymphoma

Hua Wang, Bi-bo Fu, Zhi-jun Wuxiao, Ya-jun Li, Li Huang, Jie Ma, Zhi-min Zhai… in Leukemia (2022)

Article

A novel model of alternative NF-κB pathway activation in anaplastic large cell lymphoma

Aberrant activation of NF-κB is the most striking oncogenic mechanism in B-cell lymphoma; however, its role in anaplastic large cell lymphomas (ALCL) has not been fully established and its activation mechanism...

Hongbo Wang, Wei Wei, **g-** Zhang, Zhihui Song, Yangyang Li, Wenming **ao… in Leukemia (2021)

Article

Pharmacological activation of nitric oxide signaling promotes human hematopoietic stem cell homing and engraftment

Danhua Xu, Min Yang, Maegan Capitano, Bin Guo, Sheng Liu, Jun Wan… in Leukemia (2021)

Article

Mesenchymal stem cells suppress leukemia via macrophage-mediated functional restoration of bone marrow microenvironment

Bone marrow (BM) mesenchymal stem cells (MSCs) are critical components of the BM microenvironment and play an essential role in supporting hematopoiesis. Dysfunction of MSCs is associated with the impaired BM ...

Chengxiang **a, Tongjie Wang, Hui Cheng, Yong Dong, Qitong Weng, Guohuan Sun… in Leukemia (2020)

Article

Phorbol ester induced ex vivo expansion of rigorously-defined phenotypic but not functional human cord blood hematopoietic stem cells: a cautionary tale demonstrating that phenotype does not always recapitulate stem cell function

Yandan Chen, Chunxu Yao, Yincheng Teng, Rongzhen Jiang, **nxin Huang, Sheng Liu… in Leukemia (2019)

Article

Blocking ATM-dependent NF-κB pathway overcomes niche protection and improves chemotherapy response in acute lymphoblastic leukemia

Bone marrow (BM) niche responds to chemotherapy-induced cytokines secreted from acute lymphoblastic leukemia (ALL) cells and protects the residual cells from chemotherapeutics in vivo. However, the underlying ...

Ya-Li Chen, Chao Tang, Meng-Yi Zhang, Wen-Li Huang, Yan Xu, Hui-Yin Sun… in Leukemia (2019)

Article

A novel slug-containing negative-feedback loop regulates SCF/c-Kit-mediated hematopoietic stem cell self-renewal

The stem cell factor (SCF)/c-Kit pathway has crucial roles in controlling hematopoietic stem cell (HSC) renewal. However, little is known about the intracellular regulation of the SCF/c-Kit pathway in HSCs. We...

Z Zhang, P Zhu, Y Zhou, Y Sheng, Y Hong, D **ang, Z Qian, J Mosenson, W-S Wu in Leukemia (2017)

Article

Activation of wnt/β-catenin signaling blocks monocyte–macrophage differentiation through antagonizing PU.1-targeted gene transcription

Y Sheng, W Ju, Y Huang, J Li, H Ozer, X Qiao, Z Qian in Leukemia (2016)

Article

CDK6-mediated repression of CD25 is required for induction and maintenance of Notch1-induced T-cell acute lymphoblastic leukemia

T-cell acute lymphoblastic leukemia (T-ALL) is a high-risk subset of acute leukemia, characterized by frequent activation of Notch1 or AKT signaling, where new therapeutic approaches are needed. We showed prev...

N Jena, J Sheng, J K Hu, W Li, W Zhou, G Lee, N Tsichlis, A Pathak, N Brown… in Leukemia (2016)

Article

Immunosuppressive human anti-CD83 monoclonal antibody depletion of activated dendritic cells in transplantation

Current immunosuppressive/anti-inflammatory agents target the responding effector arm of the immune response and their nonspecific action increases the risk of infection and malignancy. These effects impact on...

T A Seldon, R Pryor, A Palkova, M L Jones, N D Verma, M Findova, K Braet… in Leukemia (2016)

Article

Dasatinib promotes the potential of proliferation and antitumor responses of human γδT cells in a long-term induction ex vivo environment

K-n Wu, Y-j Wang, Y He, Y-x Hu, H-r Fu, L-x Sheng, B-s Wang, S Fu, H Huang in Leukemia (2014)