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Article
Prostaglandin E1 (Misoprostol) overcomes the adverse effect of chronic cigarette smoking on duodenal ulcer healing
Chronic cigarette smoking adversely affects duodenal ulcer healing despite treatment by potent gastric acid-reducing agents. Prostaglandins of the E series possess antisecretory and cytoprotective properties a...
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Article
Response of an ocular melanoma to subconjunctival injection of 5-Thio-D-glucose or cis-platin
Successful treatment of ocular tumours by chemotherapy and radiotherapy is sometimes limited by the special nature of the eye. Improvement is needed to avoid enucleation. Previous studies using locally adminis...
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Article
Persistence ofCampylobacter pyloridis despite healing of duodenal ulcer and improvement of accompanying duodenitis and gastritis
Campylobacter pyloridis has been associated with antral gastritis and duodenal ulcer. To study the pathogenetic role of these organisms in duodenal ulcer, endoscopic biopsies, two from the first part of duodenum...
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Article
Expression of histocompatibility antigens and characterisation of mononuclear cell infiltrates in human renal cell carcinomas
Neoplastic tissue was obtained at operation from 10 renal cell carcinomas, from the adjacent 'normal' kidney in 6 cases and from 1 other normal kidney. The biopsies were snap frozen in liquid nitrogen and sect...
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Article
Lung uptake of 131I-metaiodobenzylguanidine in sheep
Circulating biogenic amines are known to be cleared by the mammalian lung. Their lung uptake is considered as an indicator of pulmonary endothelial integrity. Unfortunately, their use as markers of pulmonary m...
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Article
Reducing meal-stimulated acid secretion versus reducing nocturnal acid secretion for healing of duodenal ulcer
Both meal-stimulated and nocturnal acid secretions have been shown to be abnormally increased in patients with duodenal ulcer. The relative efficacy of an acid-reducing regimen aimed specifically at controllin...
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Article
Pathogenetic role ofHelicobacter pylori in duodenal ulcer disease
The pathogenesis of duodenal ulcer disease is multifactorial and the contribution ofHelicobacter pylori in relation to the other factors to the release of duodenal ulcer is unknown. To investigate this, we studie...
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Article
A comparison of in vivo and in vitro 31P NMR spectra from human breast tumours: variations in phospholipid metabolism
An in vivo 31P NMR spectrum was obtained from each of four human breast tumours. The phosphomonoester and phosphodiester region of each spectrum consisted of a broad peak. Chemical extracts from samples of eac...
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Article
A phase II clinical and pharmacokinetic study of Lonidamine in patients with advanced breast cancer
Lonidamine is a substituted indazole carboxylic acid with a unique mechanism of action and early clinical studies have reported anti-tumour activity. In a phase II study 32 patients with previously treated adv...
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Article
The phosphocholine and glycerophosphocholine content of an oestrogen-sensitive rat mammary tumour correlates strongly with growth rate
An oestrogen sensitive rat mammary tumour was grown in two groups of female and one group of male hooded rats. The male group and one of the female groups were supplemented with oestrogen. The tumours grew mos...
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Article
Radioimmunotherapy for unresectable hepatocellular carcinoma using131I-Hepama-1 mAb: preliminary results
Twenty-three patients with surgically verified unresectable hepatocellular carcinoma (HCC) have been treated by intrahepatic arterial administration of131I-labeled anti-HCC monoclonal antibody (Hepama-1) combined...
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Article
Testicular function following the treatment of Hodgkin's disease in childhood
Testicular function was studied in 40 males treated in childhood for Hodgkin's disease at St Bartholomew's Hospital, and the Hospital for Sick Children, London, between 1971-1985. All patients were 16 years or...
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Article
Role ofHelicobacter pylori in cirrhotic patients with peptic ulcer
Helicobacter pylori was found to be a promoter factor of peptic ulcer that has an incidence higher in patients with hepatic cirrhosis. To clarify the role betweenH. pylori and peptic ulcer in patients with hepat...
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Article
Breast cancer angiogenesis: A quantitative morphologic and doppler imaging study
Background: Tumor growth and metastases require the development of new vessels (angiogenesis). Angiogenesis, assessed by microvessel count using immunocytochemical stain of endothelial cells, has been shown to p...
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Article
Occult breast carcinoma — Use of color Doppler in localization
Occult breast carcinoma presenting with axillary metastases is a difficult clinical problem. Mammography is recommended as the diagnostic tool for detecting breast masses, but is very insensitive. In two conse...
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Article
Breast cancer vascularity: Color Doppler sonography and histopathology study
In this prospective study, the authors examined 50 patients with breast tumors (malignant, n = 32; benign, n = 18) to investigate the correlation between color Doppler flow map** and histopathological findin...
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Article
Tuberculous colitis
Purpose: This study was undertaken to elucidate characteristic findings of tuberculous (TB) colitis at double-contrast barium enema examination (DCBE). MATERIALS AND METHODS: Twenty-five patients with TB colit.....
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Chapter and Conference Paper
Expression of Adhesion Molecules on Blood Derived CD34 Positive Cells Immediately After Thawing and After Ex Vivo Incubation with Cytokines
In order to understand the role of specific cell adhesion for stem cell engraftment after autologous transplantation we investigated the expression of adhesion molecules on blood derived CD34 positive cells fr...
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Chapter
The Therapeutic Effect of Naturin-2 on Lewis Lung Carcinoma and Murine-AIDS
The immune system plays a major role in immuno-surveillance, and its impairment has been linked to cancer and immuno-deficiency disorders including AIDS. (1–3) The biological response modifier (BRM) is a term ...
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Article
POEMS syndrome: report on six patients with unusual clinical signs, elevated levels of cytokines, macrophage involvement and chromosomal aberrations of bone marrow plasma cells
POEMS syndrome is a multisystemic disorder characterized by the association of polyneuropathy, organomegaly, endocrinopathy, M protein, skin changes and various other systemic clinical signs. The pathophysiolo...
