409 Result(s)

Article

Combinatorial macrophage induced innate immunotherapy against Ewing sarcoma: Turning “Two Keys” simultaneously

Macrophages play important roles in phagocytosing tumor cells. However, tumors escape macrophage phagocytosis in part through the expression of anti-phagocytic signals, most commonly CD47. In Ewing sarcoma (ES...

Wen Luo, Hai Hoang, Katherine E. Miller… in Journal of Experimental & Clinical Cancer … (2024)

Article

Targeted inhibition of DHODH is synergistic with BCL2 blockade in HGBCL with concurrent MYC and BCL2 rearrangement

High-grade B-cell lymphoma (HGBCL), the subtype of non-Hodgkin lymphoma, to be relapsed or refractory in patients after initial therapy or salvage chemotherapy. Dual dysregulation of MYC and BCL2 is one of the...

Lin Liu, Wenbin Mo, Miao Chen, Yi Qu, **** Wang, Ying Liang, **ao**g Yan in BMC Cancer (2024)

Article

QL1209 (pertuzumab biosimilar) versus reference pertuzumab plus trastuzumab and docetaxel in neoadjuvant treatment for HER2-positive, ER/PR-negative, early or locally advanced breast cancer: A multicenter, randomized, double-blinded, parallel-controlled, phase III equivalence trial

This randomized, parallel-controlled, double-blinded, phase III equivalence study evaluated the equivalence of a proposed pertuzumab biosimilar QL1209 to the pertuzumab (Perjeta®) each with trastuzumab and doc...

Wenjia Zuo, Zhonghua Wang, Jun Qian, **aopeng Ma, Zhaofeng Niu… in British Journal of Cancer (2024)

Article

CRISPR/Cas9-based genome-wide screening for metastasis ability identifies FCGR1A regulating the metastatic process of ovarian cancer by targeting LSP1

Metastasis is a main cause of death from ovarian cancer (OC). Identifying key markers involved in OC metastasis can aid in the effective detection of early postoperative metastasis. However, the role of FCGR1A...

Yingying Qi, Weiyan Zhu, Kexin Mo, Hui Jiang in Journal of Cancer Research and Clinical On… (2024)

Article

Effects of concurrent chemoradiotherapy with or without Endostar on the regression of retropharyngeal lymph node and prognosis of patients with locally advanced nasopharyngeal carcinoma: a retrospective study

To investigate the effect of combining Endostar with concurrent chemoradiotherapy (ECCRT) compared to concurrent chemoradiotherapy (CCRT) on the regression rate of retropharyngeal lymph nodes (RLNs) and the re...

Jun-Mei Song, Ning Mo, Yu-Qing Lv… in Journal of Cancer Research and Clinical On… (2024)

Article

The correlation study between TOP2A gene expression in circulating tumor cells and chemotherapeutic drug resistance of patients with breast cancer

Patients with breast cancer (BC) at advanced stages have poor outcomes because of high rate of recurrence and metastasis. Biomarkers for predicting prognosis remain to be explored. This study aimed to evaluate...

**-hui Ye, Jian Yu, Ming-ying Huang, Yue-mei Mo in Breast Cancer (2024)

Article

Ethanol responsive lnc171 promotes migration and invasion of HCC cells via mir-873-5p/ZEB1 axis

Long nonconding RNAs (lncRNAs) have been found to be a vital regulatory factor in the development process of human cancer, and could regarded as diagnostic or prognostic biomarkers for human cancers. Here, we ...

Shi** Huang, Zhouxiang Liao, **ao He, Zhenyu Song, ** Fang, Sha Wen… in BMC Cancer (2024)

Article

Association of serum 25-hydroxy-vitamin D concentration and risk of mortality in cancer survivors in the United States

Cancer survivors have a high risk of mortality, and vitamin D (VD) is associated with the risk of mortality. This study is aim to examine the impact of VD on mortality in cancer survivors.

**aofei Mo, Chen He, Fengfeng Han, Hui Yan, Xueqin Chen, Yuetao Wang… in BMC Cancer (2024)

Article

Desmoglein 2 and desmocollin 2 depletions promote malignancy through distinct mechanisms in triple-negative and luminal breast cancer

Aberrant expressions of desmoglein 2 (Dsg2) and desmocollin 2(Dsc2), the two most widely distributed desmosomal cadherins, have been found to play various roles in cancer in a context-dependent manner. Their s...

Ji-Yuan Han, Na Che, **g Mo, Dan-Fang Zhang, **ao-Hui Liang, Xue-Yi Dong… in BMC Cancer (2024)

Article

siRNA treatment targeting integrin α11 overexpressed via EZH2-driven axis inhibits drug-resistant breast cancer progression

Breast cancer, the most prevalent cancer in women worldwide, faces treatment challenges due to drug resistance, posing a serious threat to patient survival. The present study aimed to identify the key molecule...

Prakash Chaudhary, Kiran Yadav, Ho ** Lee, Keon Wook Kang… in Breast Cancer Research (2024)

Article

A novel engineered IL-21 receptor arms T-cell receptor-engineered T cells (TCR-T cells) against hepatocellular carcinoma

Strategies to improve T cell therapy efficacy in solid tumors such as hepatocellular carcinoma (HCC) are urgently needed. The common cytokine receptor γ chain (γ_c) family cytokines such as IL-2, IL-7, IL-15 and I...

Wei Zhu, Zhiming Zhang, **zhang Chen… in Signal Transduction and Targeted Therapy (2024)

Article

Evaluation of next-generation sequencing versus next-generation flow cytometry for minimal-residual-disease detection in Chinese patients with multiple myeloma

To evaluate the efficacy of next-generation sequencing (NGS) in minimal-residual-disease (MRD) monitoring in Chinese patients with multiple myeloma (MM).

Mo Zhou, Yan Chen, Yanlei Gong, Mingqing Zhu, Jiannong Cen, **lan Pan… in Discover Oncology (2024)

Article

The construction of modular universal chimeric antigen receptor T (MU-CAR-T) cells by covalent linkage of allogeneic T cells and various antibody fragments

Chimeric antigen receptor-T (CAR-T) cells therapy is one of the novel immunotherapeutic approaches with significant clinical success. However, their applications are limited because of long preparation time, h...

Tao Chen, Jieyi Deng, Yongli Zhang, Bingfeng Liu, Ruxin Liu… in Molecular Cancer (2024)

Article

Unrelated donor hematopoietic stem cell transplantation compared to immunosuppressive therapy plus eltrombopag as first-line treatment for adults with severe aplastic anemia

Liangliang Wu, Limin Liu, **n Zhao, Ming Zhou, Andie Fu… in Blood Cancer Journal (2024)

Article

Inhibition of growth of hepatocellular carcinoma by co-delivery of anti-PD-1 antibody and sorafenib using biomimetic nano-platelets

Traditional nanodrug delivery systems have some limitations, such as eliciting immune responses and inaccuracy in targeting tumor microenvironments.

Xuanbo Da, Bang** Cao, Jiantao Mo, Yukai **ang, Hai Hu, Chen Qiu… in BMC Cancer (2024)

Article

Prognostic value of CT-based radiomics in grade 1–2 pancreatic neuroendocrine tumors

Surgically resected grade 1–2 (G1-2) pancreatic neuroendocrine tumors (PanNETs) exhibit diverse clinical outcomes, highlighting the need for reliable prognostic biomarkers. Our study aimed to develop and valid...

Subin Heo, Hyo Jung Park, Hyoung Jung Kim, Jung Hoon Kim, Seo Young Park… in Cancer Imaging (2024)

Article

Atovaquone enhances antitumor efficacy of TCR-T therapy by augmentation of ROS-induced ferroptosis in hepatocellular carcinoma

T-cell receptor (TCR) engineered T-cell therapy has recently emerged as a promising adoptive immunotherapy approach for tumor treatment, yet hindered by tumor immune evasion resulting in poor therapeutic effic...

Anan Chen, Zhiwu Yu, Na Ma, **nyu Lu, Ya**g Zhang… in Cancer Immunology, Immunotherapy (2024)

Article

Efficacies of anlotinib monotherapy versus gemcitabine-based chemotherapy for patients with advanced soft tissue sarcoma after the failure of anthracycline-based chemotherapy

The purpose of this study was to compare the antitumor efficacy of anlotinib with gemcitabine-based chemotherapy as subsequent treatment regimens in patients with advanced non-specific soft tissue sarcoma (STS...

Ai** Zheng, Jie Liu, Zi**g Liu, Zeming Mo… in Journal of Cancer Research and Clinical On… (2024)

Article

Clinical activity and safety of sintilimab, bevacizumab, and TMZ in patients with recurrent glioblastoma

There are limited and no standard therapies for recurrent glioblastoma. We herein report the antitumour activity and safety of sintilimab, bevacizumab and temozolomide (TMZ) in recurrent glioblastoma.

Yinghao Lu, Limin Liao, Kunpeng Du, Jianhua Mo, **a Zou, Junxian Liang… in BMC Cancer (2024)