163 Result(s)

Article

Targeted inhibition of DHODH is synergistic with BCL2 blockade in HGBCL with concurrent MYC and BCL2 rearrangement

High-grade B-cell lymphoma (HGBCL), the subtype of non-Hodgkin lymphoma, to be relapsed or refractory in patients after initial therapy or salvage chemotherapy. Dual dysregulation of MYC and BCL2 is one of the...

Lin Liu, Wenbin Mo, Miao Chen, Yi Qu, **** Wang, Ying Liang, **ao**g Yan in BMC Cancer (2024)

Article

QL1209 (pertuzumab biosimilar) versus reference pertuzumab plus trastuzumab and docetaxel in neoadjuvant treatment for HER2-positive, ER/PR-negative, early or locally advanced breast cancer: A multicenter, randomized, double-blinded, parallel-controlled, phase III equivalence trial

This randomized, parallel-controlled, double-blinded, phase III equivalence study evaluated the equivalence of a proposed pertuzumab biosimilar QL1209 to the pertuzumab (Perjeta®) each with trastuzumab and doc...

Wenjia Zuo, Zhonghua Wang, Jun Qian, **aopeng Ma, Zhaofeng Niu… in British Journal of Cancer (2024)

Article

Deciphering Müller cell heterogeneity signatures in diabetic retinopathy across species: an integrative single-cell analysis

Diabetic retinopathy (DR), a leading cause of visual impairment, demands a profound comprehension of its cellular mechanisms to formulate effective therapeutic strategies. Our study presentes a comprehensive s...

**yuan Deng, Ya Mo, **uying Zhu in European Journal of Medical Research (2024)

Article

Ethanol responsive lnc171 promotes migration and invasion of HCC cells via mir-873-5p/ZEB1 axis

Long nonconding RNAs (lncRNAs) have been found to be a vital regulatory factor in the development process of human cancer, and could regarded as diagnostic or prognostic biomarkers for human cancers. Here, we ...

Shi** Huang, Zhouxiang Liao, **ao He, Zhenyu Song, ** Fang, Sha Wen… in BMC Cancer (2024)

Article

Association of serum 25-hydroxy-vitamin D concentration and risk of mortality in cancer survivors in the United States

Cancer survivors have a high risk of mortality, and vitamin D (VD) is associated with the risk of mortality. This study is aim to examine the impact of VD on mortality in cancer survivors.

**aofei Mo, Chen He, Fengfeng Han, Hui Yan, Xueqin Chen, Yuetao Wang… in BMC Cancer (2024)

Article

Desmoglein 2 and desmocollin 2 depletions promote malignancy through distinct mechanisms in triple-negative and luminal breast cancer

Aberrant expressions of desmoglein 2 (Dsg2) and desmocollin 2(Dsc2), the two most widely distributed desmosomal cadherins, have been found to play various roles in cancer in a context-dependent manner. Their s...

Ji-Yuan Han, Na Che, **g Mo, Dan-Fang Zhang, **ao-Hui Liang, Xue-Yi Dong… in BMC Cancer (2024)

Article

Unrelated donor hematopoietic stem cell transplantation compared to immunosuppressive therapy plus eltrombopag as first-line treatment for adults with severe aplastic anemia

Liangliang Wu, Limin Liu, **n Zhao, Ming Zhou, Andie Fu… in Blood Cancer Journal (2024)

Article

Tibial cortex transverse transport promotes ischemic diabetic foot ulcer healing via enhanced angiogenesis and inflammation modulation in a novel rat model

Tibial Cortex Transverse Transport (TTT) represents an innovative surgical method for treating lower extremity diabetic foot ulcers (DFUs), yet its underlying mechanisms remain elusive. Establishing an animal ...

Wencong Qin, Kaibin Liu, Hongjie Su, Jun Hou… in European Journal of Medical Research (2024)

Article

Inhibition of growth of hepatocellular carcinoma by co-delivery of anti-PD-1 antibody and sorafenib using biomimetic nano-platelets

Traditional nanodrug delivery systems have some limitations, such as eliciting immune responses and inaccuracy in targeting tumor microenvironments.

Xuanbo Da, Bang** Cao, Jiantao Mo, Yukai **ang, Hai Hu, Chen Qiu… in BMC Cancer (2024)

Article

Clinical activity and safety of sintilimab, bevacizumab, and TMZ in patients with recurrent glioblastoma

There are limited and no standard therapies for recurrent glioblastoma. We herein report the antitumour activity and safety of sintilimab, bevacizumab and temozolomide (TMZ) in recurrent glioblastoma.

Yinghao Lu, Limin Liao, Kunpeng Du, Jianhua Mo, **a Zou, Junxian Liang… in BMC Cancer (2024)

Article

MRD positivity was the poor prognostic factor for adverse-risk AML patients with allogeneic hematopoietic stem cell transplantation: a multicenter TROPHY study

Yang Cao, Wenxuan Huo, Jiayu Huang, Yang Yang, Yu Wang… in Blood Cancer Journal (2024)

Article

Adjuvant medial versus entire supraclavicular lymph node irradiation in high-risk early breast cancer (SUCLANODE): a protocol for a multicenter, randomized, open-label, phase 3 trial

Supraclavicular nodal (SCL) irradiation is commonly used for patients with high-risk breast cancer after breast surgery. The Radiation Therapy Oncology Group (RTOG) and European Society for Radiotherapy and On...

Li Zhang, **n Mei, Zhigang Hu, Bo Yu, Chaoyang Zhang, Yong Li, Kaitai Liu… in BMC Cancer (2024)

Article

Prognostic potential of preoperative circulating tumor cells to predict the early progression recurrence in hepatocellular carcinoma patients after hepatectomy

The role of circulating tumor cells (CTCs) in prognosis prediction has been actively studied in hepatocellular carcinoma (HCC) patients. However, their efficiency in accurately predicting early progression rec...

Zhan Lu, Hanghang Ni, **hua Yang, Lihao Tan, Haixiao Zhuang, Yunning Mo… in BMC Cancer (2023)

Article

The optimal intravesical maintenance chemotherapy scheme for the intermediate-risk group non-muscle-invasive bladder cancer

Although the current European Association of Urology(EAU) guideline recommends that patients with intermediate-risk non-muscle-invasive bladder cancer (NMIBC) should accept intravesical chemotherapy or Calmett...

Jian-**n Chen, Wen-Ting Huang, Qing-Yun Zhang, Cheng-En Deng, Jue-ling Wei… in BMC Cancer (2023)

Article

Analysis of m7G-Related signatures in the tumour immune microenvironment and identification of clinical prognostic regulators in breast cancer

Breast cancer is a malignant tumour that seriously threatens women’s life and health and exhibits high inter-individual heterogeneity, emphasising the need for more in-depth research on its pathogenesis. While...

Qinghua Huang, Jianlan Mo, Huawei Yang, Yinan Ji, Rong Huang, Yan Liu… in BMC Cancer (2023)

Article

Integrative molecular subtypes of acute myeloid leukemia

Qianxing Mo, Seongseok Yun, David A. Sallman, Nicole D. Vincelette… in Blood Cancer Journal (2023)