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  1. No Access

    Article

    Breaking barriers to transcription elongation

  2. Many RNA polymerase II (Pol II)-transcribed genes are regulated at the level of transcription elongation, which has three main stages: promoter escape, promote...

    3. Abbie Saunders, Leighton J. Core, John T. Lis in Nature Reviews Molecular Cell Biology (2006)

  3. No Access

    Article

    Analysis of nascent RNA identifies a unified architecture of initiation regions at mammalian promoters and enhancers

    John Lis, Adam Siepel and colleagues map transcription start sites across the genome in two human cell lines using a nuclear run-on protocol called GRO-cap. They find a common architecture of initiation at bot...

    Leighton J Core, André L Martins, Charles G Danko, Colin T Waters… in Nature Genetics (2014)

  4. No Access

    Article

    Chromatin run-on and sequencing maps the transcriptional regulatory landscape of glioblastoma multiforme

    The human genome encodes a variety of poorly understood RNA species that remain challenging to identify using existing genomic tools. We developed chromatin run-on and sequencing (ChRO-seq) to map the location...

    Tinyi Chu, Edward J. Rice, Gregory T. Booth, H. Hans Salamanca… in Nature Genetics (2018)