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Article
Novel therapies with precision mechanisms for type 2 diabetes mellitus
Type 2 diabetes mellitus (T2DM) is one of the greatest health crises of our time and its prevalence is projected to increase by >50% globally by 2045. Currently, 10 classes of drugs are approved by the US Food...
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Article
Physiological factors contributing to HbA1c in the normal and pre-diabetic range: a cross-sectional analysis
Little is known about the underlying physiology that contributes to Haemoglobin A1c (HbA1c) in the normal and pre-diabetic range. We determined the contribution of fasting plasma glucose (FPG), 2-h plasma glucose...
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Article
Open AccessThe Association Between Type 2 Diabetes and Cardiovascular Disease: The “For Your SweetHeart™” Survey
It is unclear whether patients and their loved ones appreciate that cardiovascular disease (CVD) is the major cause of morbidity and mortality in type 2 diabetes mellitus (T2DM). The purpose of this survey was...
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Article
Open AccessOptimizing Fixed-Ratio Combination Therapy in Type 2 Diabetes
The progressive nature of type 2 diabetes (T2D) means that many patients will require basal insulin therapy at some point in the course of the disease due to β-cell failure. As basal insulin primarily targets ...