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    Article

    Novel therapies with precision mechanisms for type 2 diabetes mellitus

    Type 2 diabetes mellitus (T2DM) is one of the greatest health crises of our time and its prevalence is projected to increase by >50% globally by 2045. Currently, 10 classes of drugs are approved by the US Food...

    Leigh Perreault, Jay S. Skyler, Julio Rosenstock in Nature Reviews Endocrinology (2021)

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    Article

    Physiological factors contributing to HbA1c in the normal and pre-diabetic range: a cross-sectional analysis

    Little is known about the underlying physiology that contributes to Haemoglobin A1c (HbA1c) in the normal and pre-diabetic range. We determined the contribution of fasting plasma glucose (FPG), 2-h plasma glucose...

    Lea Bruhn, Dorte Vistisen, Camilla Trine Ravn Vainø, Leigh Perreault in Endocrine (2020)

  3. Article

    Open Access

    The Association Between Type 2 Diabetes and Cardiovascular Disease: The “For Your SweetHeart™” Survey

    It is unclear whether patients and their loved ones appreciate that cardiovascular disease (CVD) is the major cause of morbidity and mortality in type 2 diabetes mellitus (T2DM). The purpose of this survey was...

    Leigh Perreault, Marilyn K. Boardman, Jonathan Pak in Advances in Therapy (2019)

  4. Article

    Open Access

    Optimizing Fixed-Ratio Combination Therapy in Type 2 Diabetes

    The progressive nature of type 2 diabetes (T2D) means that many patients will require basal insulin therapy at some point in the course of the disease due to β-cell failure. As basal insulin primarily targets ...

    Leigh Perreault, Helena Rodbard, Virginia Valentine, Eric Johnson in Advances in Therapy (2019)