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    Article

    A kinetic view of GPCR allostery and biased agonism

    Allosteric modulation and biased agonism at GPCRs could be manifestations of the same underlying 'conformational selection' mechanism, and these can be harmonized by considering the influence of ligand–recepto...

    J Robert Lane, Lauren T May, Robert G Parton, Patrick M Sexton… in Nature Chemical Biology (2017)

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    Chapter

    Bifunctional Tools to Study Adenosine Receptors

    Target-based G protein-coupled receptors (GPCRs) drug discovery has historically focused on the development of ligands that either activate or inhibit the signal response of one specific receptor. However, the...

    China Payne, Jon K. Awalt, Lauren T. May… in Purinergic Receptors and their Modulators (2023)