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  1. No Access

    Article

    Structure-Based Neuron Retrieval Across Drosophila Brains

    Comparing local neural structures across large sets of examples is crucial when studying gene functions, and their effect in the Drosophila brain. The current practice of aligning brain volume data to a joint ...

    Florian Ganglberger, Florian Schulze, Laszlo Tirian, Alexey Novikov… in Neuroinformatics (2014)

  2. No Access

    Article

    Adaptive and Background-Aware GAL4 Expression Enhancement of Co-registered Confocal Microscopy Images

    GAL4 gene expression imaging using confocal microscopy is a common and powerful technique used to study the nervous system of a model organism such as Drosophila melanogaster. Recent research projects focused on ...

    Martin Trapp, Florian Schulze, Alexey A. Novikov, Laszlo Tirian… in Neuroinformatics (2016)

  3. No Access

    Article

    A heterochromatin-dependent transcription machinery drives piRNA expression

    Nuclear small RNA pathways safeguard genome integrity by establishing transcription-repressing heterochromatin at transposable elements. This inevitably also targets the transposon-rich source loci of the smal...

    Peter Refsing Andersen, Laszlo Tirian, Milica Vunjak, Julius Brennecke in Nature (2017)

  4. No Access

    Article

    Panoramix SUMOylation on chromatin connects the piRNA pathway to the cellular heterochromatin machinery

    Nuclear Argonaute proteins, guided by small RNAs, mediate sequence-specific heterochromatin formation. The molecular principles that link Argonaute-small RNA complexes to cellular heterochromatin effectors on ...

    Veselin I. Andreev, Changwei Yu, Juncheng Wang… in Nature Structural & Molecular Biology (2022)