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Article
Open AccessAntibodies elicited by the first non-viral prophylactic cancer vaccine show tumor-specificity and immunotherapeutic potential
MUC1 is a shared tumor antigen expressed on >80% of human cancers. We completed the first prophylactic cancer vaccine clinical trial based on a non-viral antigen, MUC1, in healthy individuals at-risk for colon...
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Article
Proteomics-directed cloning of circulating antiviral human monoclonal antibodies
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Article
A proteomics approach for the identification and cloning of monoclonal antibodies from serum
The ability to identify antibodies circulating in the bloodstream would advance immunology and vaccinology research and the development of therapeutics. Cheung et al. couple proteomics with next-generation sequen...
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Article
Pattern recognition receptors TLR4 and CD14 mediate response to respiratory syncytial virus
The innate immune system contributes to the earliest phase of the host defense against foreign organisms and has both soluble and cellular pattern recognition receptors for microbial products. Two important me...
