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  1. Article

    Open Access

    Targeting heat-shock protein 90 with ganetespib for molecularly targeted therapy of gastric cancer

    Gastric cancer (GC) remains the fifth most common cancer worldwide. Heat-shock protein 90 (HSP90) has become an attractive therapeutic target in treating cancers, because of its abnormally high expression in c...

    H Liu, J Lu, Y Hua, P Zhang, Z Liang, L Ruan, C Lian, H Shi, K Chen… in Cell Death & Disease (2015)

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  2. Article

    Open Access

    Biological significance of FoxN1 gain-of-function mutations during T and B lymphopoiesis in juvenile mice

    FoxN1 is cell-autonomously expressed in skin and thymic epithelial cells (TECs), essential for their development. Inborn mutation of FoxN1 results in hair follicle and TEC development failure, whereas insufficien...

    L Ruan, Z Zhang, L Mu, P Burnley, L Wang, B Coder, Q Zhuge, D-M Su in Cell Death & Disease (2014)

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  3. No Access

    Article

    Microcalorimetric studies on the polyhydroxyalkanoates production of recombinant Escherichia Coli

    The thermogenic curves of metabolism of two strains of Escherichia coli pUC19cab/XL-IBlue and XL-IBlue have been determined by using a LKB-2277 bioActivity Monitor and ampoule method at 37°C. pUC19cab/XL-IBlue wa...

    L. Ruan, Y. Wang, Q. Yan, P. H. Yu in Applied Biochemistry and Microbiology (2006)

  4. No Access

    Article

    Cloning and expression of mel gene from Bacillus thuringiensis in Escherichia coli

    Previous work from our laboratory has shown that most of Bacillus thuringiensis strains possess the ability to produce melanin in the presence of l-tyrosine at elevated temperatures (42 °C). Furthermore, it was s...

    L. Ruan, W. He, J. He, M. Sun, Z. Yu in Antonie van Leeuwenhoek (2005)