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Article
The unfolded protein response controls induction and activation of ADAM17/TACE by severe hypoxia and ER stress
The family of ADAM (a disintegrin and metalloproteinase) proteins has been implicated in tumor initiation and progression. ADAM17/tumor necrosis factor-α (TNFα)-converting enzyme (TACE) has been initially reco...
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Article
Regulation of autophagy by ATF4 in response to severe hypoxia
Activating transcription factor 4 (ATF4) is a transcription factor induced under severe hypoxia and a component of the PERK pathway involved in the unfolded protein response (UPR), a process that protects cell...