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Article
High frequency of RUNX1 mutation in myelodysplastic syndrome patients with whole-arm translocation of der(1;7)(q10;p10)
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Article
Exome sequencing identifies highly recurrent somatic GATA2 and CEBPA mutations in acute erythroid leukemia
Acute erythroid leukemia (AEL), characterized by a predominant erythroid proliferation, is a subtype of acute myelogenous leukemia. The genetic basis of AEL remains poorly defined. Through whole-exome sequenci...
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Article
Open AccessCrucial roles of the CHRNB3–CHRNA6 gene cluster on chromosome 8 in nicotine dependence: update and subjects for future research
Cigarette smoking is a leading cause of preventable death throughout the world. Nicotine, the primary addictive compound in tobacco, plays a vital role in the initiation and maintenance of its use. Nicotine ex...
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Article
B23 acts as a nucleolar stress sensor and promotes cell survival through its dynamic interaction with hnRNPU and hnRNPA1
The nucleolus is one of the functional nuclear compartments in which the ribosome biogenesis takes place. Proteomic analysis revealed a large number of nucleolar proteins that are involved in diverse cellular ...
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Article
FREQUENCY OF LIVER MEMBRANE SPECIFIC T LYMPHOCYTES IN AUTOIMMUNE CHRONIC ACTIVE HEPATITIS (aCAH)
We have previously shown that children with aCAH have circulating activated T lymphocytes specifically sensitised to liver cell membrane, which are involved in mediating liver damage. To determine the frequenc...
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Article
LIVER MEMBRANE-SPECIFIC T CEL CLONES IN AUTOIMMUNE CHRONIC ACTIVE HEPATITIS (aCAH)
Patients with a CAH have increased numbers of activated circulating T-lymphocytes expressing interleukin 2 receptors (IL-2R). By sequentially incubating peripheral blood mononuclear cells (PBMC) of a patient w...