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  1. No Access

    Article

    In vitro and in vivo antiherpetic effects of (1R,2R)-1-(5′-methylful-3′-yl)propane-1,2,3-triol

    In this study, we demonstrated the in vitro and in vivo antiherpetic activities of a stable furan derivative, (1R,2R)-1-(5′-methylful-3′-yl)propane-1,2,3-triol (MFPT), which had originally been isolated from Stre...

    Kohei Sasaki, Kyoko Hayashi, Yuji Matsuya, Kenji Sugimoto… in Journal of Natural Medicines (2016)

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    Article

    Topical application of polyethylenimine as a candidate for novel prophylactic therapeutics against genital herpes caused by herpes simplex virus

    Herpes simplex virus types 1 (HSV-1) and 2 (HSV-2) cause genital herpes, which can enhance the acquisition of human immunodeficiency virus. The development of anti-HSV agents with novel mechanisms of action is...

    Kyoko Hayashi, Hiroki Onoue, Kohei Sasaki, Jung-Bum Lee… in Archives of Virology (2014)

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    Article

    In vitro and in vivo evaluation of a novel antiherpetic flavonoid, 4′-phenylflavone, and its synergistic actions with acyclovir

    The development of therapeutic agents for preventing herpes simplex virus (HSV) infections has become urgently necessary because of the increasing incidence of this virus and its role as a cofactor in the tran...

    Kyoko Hayashi, Munekazu Iinuma, Kohei Sasaki, Toshimitsu Hayashi in Archives of Virology (2012)

  4. No Access

    Article

    Potent virucidal effect of pheophorbide a and pyropheophorbide a on enveloped viruses

    In this study, we evaluated the inhibitory effect of ethanol and aqueous extracts from a stem of Opuntia ficus indica on replication of three kinds of viruses: two enveloped viruses [herpes simplex virus type 2 (...

    Lamjed Bouslama, Kyoko Hayashi, Jung-Bum Lee… in Journal of Natural Medicines (2011)

  5. No Access

    Article

    Two new monoterpenes from Sibiraea angustata

    Two novel monoterpenes, sibiscolacton (1) and sibiraic acid (2), were isolated from the aerial part of Sibiraea angustata Rchd. along with seven known compounds, namely three phenylpropanoids (3–5), two flavonoid...

    Bin Li, Jung-Bum Lee, Kyoko Hayashi, Yoshiaki Ito… in Journal of Natural Medicines (2010)

  6. No Access

    Article

    Potentiation of ganciclovir toxicity in the herpes simplex virus thymidine kinase/ganciclovir administration system by ponicidin

    The herpes simplex virus thymidine kinase (HSV-TK)/ganciclovir (GCV) administration system is commonly used in gene therapy trials. We have evaluated the effect of ponicidin, a diterpenoid isolated from a plant,

    Kyoko Hayashi, Toshimitsu Hayashi, Han-Dong Sun, Yoshio Takeda in Cancer Gene Therapy (2000)