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TGF-β induces assembly of a Smad2–Smurf2 ubiquitin ligase complex that targets SnoN for degradation

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  1. Article

    Ski and SnoN, potent negative regulators of TGF-β signaling

    Ski and the closely related SnoN were discovered as oncogenes by their ability to transform chicken embryo fibroblasts upon overexpression. While elevated expressions of Ski and SnoN have also been reported in...

    Julien Deheuninck, Kunxin Luo in Cell Research (2009)

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  2. Article

    Open Access

    Simultaneous silencing of two different Arabidopsis genes with a novel virus-induced gene silencing vector

    Virus-induced gene silencing (VIGS) is a useful tool for functional characterizations of plant genes. However, the penetrance of VIGS varies depending on the genes to be silenced, and has to be evaluated by ex...

    Kunxin Wu, Yadan Wu, Chunwei Zhang, Yan Fu, Zhixin Liu, **uchun Zhang in Plant Methods (2021)

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  3. Article

    Open Access

    Blockade of the ADAM8-Fra-1 complex attenuates neuroinflammation by suppressing the Map3k4/MAPKs axis after spinal cord injury

    Mechanical spinal cord injury (SCI) is a deteriorative neurological disorder, causing secondary neuroinflammation and neuropathy. ADAM8 is thought to be an extracellular metalloproteinase, which regulates prot...

    Zhanyang Qian, Rulin Li, Tianyu Zhao, Kunxin **e… in Cellular & Molecular Biology Letters (2024)

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