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Article
Open AccessExpression of epithelial-mesenchymal transition-related markers and phenotypes during breast cancer progression
The study aimed to investigate expression of epithelial-to-mesenchymal transition (EMT)-related proteins and phenotypes during breast cancer progression and to relate this to patient outcome.
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Article
Open AccessSerial evaluation of serum thymidine kinase activity is prognostic in women with newly diagnosed metastatic breast cancer
The rapid development of new therapies in metastatic breast cancer (MBC), entails a need for improved prognostic and monitoring tools. Thymidine kinase 1 (TK1) is involved in DNA synthesis and its activity cor...
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Article
Open AccessLongitudinal enumeration and cluster evaluation of circulating tumor cells improve prognostication for patients with newly diagnosed metastatic breast cancer in a prospective observational trial
Circulating tumor cells (CTCs) carry independent prognostic information in patients with metastatic breast cancer (MBC) on different lines of therapy. Moreover, CTC clusters are suggested to add prognostic inf...
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Article
Open AccessThe PDGF pathway in breast cancer is linked to tumour aggressiveness, triple-negative subtype and early recurrence
The platelet-derived growth factor (PDGF) signalling pathway is often dysregulated in cancer and PDGF-receptor expression has been linked to unfavourable prognostic factors in breast cancer (e.g. ER negativity...
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Article
Open AccessA novel method for downstream characterization of breast cancer circulating tumor cells following CellSearch isolation
Enumeration of circulating tumor cells (CTCs) obtained from minimally invasive blood samples has been well established as a valuable monitoring tool in metastatic and early breast cancer, as well as in several...
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Article
Open AccessNo evidence for shedding of circulating tumor cells to the peripheral venous blood as a result of mammographic breast compression
This pilot study aimed to investigate whether mammographic compression procedures might cause shedding of tumor cells into the circulatory system as reflected by circulating tumor cell (CTC) count in periphera...
