4 Result(s)
within
Kong** Wu
Cancer Research
Pathology
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Chapter
Inhibition of Breast Tumor Stem Cells Expansion by the Endogenous Cell Fate Determination Factor Dachshund
The Dachshund homolog 1 (Dach1) gene encodes a conserved co-repressor protein that, through its interaction with other nuclear proteins in the context of the local chromatin, participates in the regulation of gen...
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Article
Open AccessTargeting lysosomes in human disease: from basic research to clinical applications
In recent years, accumulating evidence has elucidated the role of lysosomes in dynamically regulating cellular and organismal homeostasis. Lysosomal changes and dysfunction have been correlated with the develo...
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Article
Open AccessTargeting polarized phenotype of microglia via IL6/JAK2/STAT3 signaling to reduce NSCLC brain metastasis
Tumor-associated macrophages have emerged as crucial factors for metastases. Microglia are indispensable components of the brain microenvironment and play vital roles in brain metastasis (BM). However, the und...
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Article
Open AccessNotch signaling pathway: architecture, disease, and therapeutics
The NOTCH gene was identified approximately 110 years ago. Classical studies have revealed that NOTCH signaling is an evolutionarily conserved pathway. NOTCH receptors undergo three cleavages and translocate i...
